Protein Alignment CAP and Sorbs2

DIOPT Version :10

• Sequence 1: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Sequence 2: XP_063131059.1
• Gene: Sorbs2 / 114901
• RGDID: 620061
• Length: 1536
• Species: Rattus norvegicus
• Alignment Length: 1761
• Identity: 389/1761 - (22%)
• Similarity: 587/1761 - (33%)
• Gaps: 651/1761 - (36%)

  Fly  1195 SHQPVSQTKRYS--NIETSSYESKKRMENGQVVY---------DVSTSSHEKKEQGDPPKDQPVP 1248
            ||.|.|..:.|:  |.||.         ||...|         .|..:..:||.    |...|:|
  Rat    38 SHSPDSAWRSYNGRNPETL---------NGDATYSSLAAKGFRSVRPNLQDKKS----PTQAPLP 89

  Fly  1249 PVPPPPIMSATKLNGNTFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQN 1313
            ||......|.:.:...:  .||:                              .|:.|..:...:
  Rat    90 PVRKGSFDSQSLITNQS--KGDI------------------------------LDSLGTNKLTPS 122

  Fly  1314 GLDQDRVFKDFDRLSQQMHAELQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQE- 1377
            ..:.....|.....::......|:.....|.|.::......|||....||...      ||..:
  Rat   123 CTEDFTNLKPLQGTTRSSEDSNQTLMYSEESSTTVSYTQKITRPLPASPRASP------AHFGDI 181

  Fly  1378 ----LEREIERSAKSR----------QERMSS-----------------VPRQMEATP-PRTH-- 1408
                |:::..:.:::|          |::.||                 :||....:| |.||
  Rat   182 NTPFLQQDYTQDSQTRRISTLKLTPNQDQGSSFPLNTPQFPQPTGSPSFLPRSCSPSPNPDTHTA 246

  Fly  1409 EIPIELEPRS-RRAESLCNLNEPPPRPHTTVGHYNHPVVQDDWSRYANDL-------------GY 1459
            .:.|.:.|.| ...||.....|.||.|      ...|:.||  .:..:|.             |.
  Rat   247 SLSIRIAPCSEHHLESHKQFPELPPEP------AKMPLQQD--RQTPSDATACQSPASHITINGN 303

  Fly  1460 SENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTN---------DLSSSSQYSYDTFNAYGGR 1515
            |.....|.:     .|||     |....|..|.||.|         .|.|:..||....:..|..
  Rat   304 SGGAVSPVS-----YYQR-----PFSPSAYSLPASLNSSIIMPHGRSLDSAETYSQHAQSLDGTM 358

  Fly  1516 RTHAPMLNQAQQQQR------PHYGSCYSMIERDPNPRYISTTSRR------------------- 1555
            .:..|:...:::::|      |||.. ...::....|..|.||..|
  Rat   359 GSSIPLYRSSEEEKRVTVIKAPHYPG-IGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPD 422

  Fly  1556 ---------------------------------------------------GVSPAPPPVATPQQ 1569
                                                               ..||.|||
  Rat   423 EDTDMYNTPYTYNAGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEAPSPVPPP------ 481

  Fly  1570 QQVPPPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERRRLME---------EMQR 1625
             .|||    |.:.:||  .|.|:..       ..:.|.:..:.:.|.|.:.|         :.:|
  Rat   482 -HVPP----RPRDQSS--TEKHDWD-------PPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER 532

  Fly  1626 APVL---PAPQRRESYR-----------------------PAAKL--PTLSEDEVFRQQMA---- 1658
            .|.|   |.|..||..|                       ||.:|  |.||.....|...|
  Rat   533 PPPLPTTPTPVPREPSRKPLPVSPSTDGLRSPSPPPRSCVPAPRLSAPDLSPTGTGRINPADIDL 597

  Fly  1659 --EEWMNKVAEREERRQHKIIRISKIEDEHDHSAVDKATISDEFLDRVKERRHKLSMPADS---- 1717
              |.|....:|.|..|......:..::| |.....::.::....:||..||      |:.|
  Rat   598 ENEPWYKFFSELEFGRPPPKKALDYVQD-HSSGVSNEVSVYQSSIDRSLER------PSSSASMA 655

  Fly  1718 -DWESGAESQPQPAAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQLPDGAQME 1781
             |:....:|:|           ...||            |.|..|       |:|...|..|
  Rat   656 GDFRKRRKSEP-----------AVGPP------------RGLGDH-------SSSRTSPGRA--- 687

  Fly  1782 RHEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRL----------- 1835
                        |...||:|..||.     :|..|.|     |.:..||:..::
  Rat   688 ------------DLPGSSSTFTTSF-----ISSSPSS-----PSRAQGGDDSKMCPPLCSYSGLN 730

  Fly  1836 ------------YR------ERSQTA-------RLVSHNIPLELTSNHSSSP-------DSDFNP 1868
                        ||      :.||.|       ::...|..:..::..:.||       |...|.
  Rat   731 GSPSSELECCGAYRRHLDVPQDSQRAITFKNGWQMARQNAEIWSSTEEAVSPKIKSRSCDDLLND 795

  Fly  1869 GCGSSPAPGSSTQSSIPSLVQSPTPAPPPPIEPLNP----------------SSSTAGGILGTAL 1917
            .|||.|.|.:.:: |:.||:.........|:...:|                |:..|.|.|.
  Rat   796 DCGSFPDPKTKSE-SMGSLLCDEGSKESDPMTWTSPYIPEVCGNSRSRLKHRSAHNAPGFLK--- 856

  Fly  1918 LLGLSLLTAWNKFIYKVKH-----EYMSEPETGSDRPRKMAQLGRRQYDGI---------GPVTN 1968
                         :||..|     :.|:.....|.:.|.:.....:|:.|:         ..|..
  Rat   857 -------------MYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPR 908

  Fly  1969 DGMPIILRSEVKEPHQHEWYKRLYQTIHKQKN-GDDFVIRYK--------CPRARPSYKSNGYVS 2024
            |.:|    :.:.|      :::|.|......| ||:.:....        ||:.|.|.:|   :.
  Rat   909 DVVP----TRISE------FEKLIQKSKSMPNLGDEMLSPVTLEPPQNGLCPKRRFSIES---LL 960

  Fly  2025 EPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVR-NLNQDEKLYGTMPNPIKSAQNSYKNQPGRIE 2088
            |.|       :.||:.:|.....:| ::.|.:. .:..||:       |....:.|..:|.|.:.
  Rat   961 EEE-------TQVRHPSQGQRSCKS-NTLVPIHIEVTSDEQ-------PRTHMEFSDSDQDGVVS 1010

  Fly  2089 NYT-----TGHSSVSEKEKKEWWDEVMDIFNGNLE----------------QSKLSPLYT----- 2127
            :::     .|.|..||.:...:.....:.|.|:..                :.:....||
  Rat  1011 DHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHRHLISSCKGRCPASYTRFTTM 1075

  Fly  2128 -------EGNLSRALAK--ESGYTSDSNLV----FRKKEVPVSSPLSPVEQKQAYKSL------- 2172
                   ..|:.|...:  :.|.:..:.||    ||:|:  |.:|....||.:...|:
  Rat  1076 LKHERAKHENIDRPRRQDMDPGLSKLAFLVSPVPFRRKK--VLTPQKQTEQAKCKASVVEALDSA 1138

  Fly  2173 ------------QAGGEPP------LLGFRKP-APEKPRDLD-----PNAPPIPPQPPVKGLSSY 2213
                        :.|..|.      |:....| .||:...|:     |...|..|.|.
  Rat  1139 LKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPERNSSLNALKRSPMHQPFHPLPQ------- 1196

  Fly  2214 DFPYSTDTVDGSDVNIHFKTPIRH----EQRQNLSEEELAIRQAEHMQ------KLYHEERRRKY 2268
                     ||:   ||  .|:..    ....:.|..::....:.|.|      .|...|..|.|
  Rat  1197 ---------DGA---IH--CPLYQNDCGRMPHSASFPDVDTTSSYHAQDYGSVLSLQDHESPRSY 1247

  Fly  2269 LQELQDMN---SRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKEL 2330
            ...|.|:.   ||....  ||.::                      .|..|:|:::|:.||||||
  Rat  1248 SSTLTDLGRSVSRERRG--TPEKE----------------------VKLPAKAVYDFKAQTSKEL 1288

  Fly  2331 SFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSK-----RPSE-GQARAKY 2389
            ||:||||:||.|:||.|||||||:..:|:.|.||||.::......|::     :|.| |:|.|||
  Rat  1289 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKY 1353

  Fly  2390 NFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI--ANRKGIFPCSYVEVL--TDIGAEDIAARTT 2450
            ||.|.:.:||||.||:.:.|.:|||.||:||||  .||:||||.|||||:  ...|:||.
  Rat  1354 NFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNTKGSEDY----- 1413

  Fly  2451 TVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDAL------------ 2503
                        |:..:..:..::...:|:.|........||...||.:....
  Rat  1414 ------------PDPPLPHSYSSDRIYSLSSNKILVLMLSLKRKETLLRVQCTGDSYQYFSYKPQ 1466

  Fly  2504 -------HVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFP 2561
                   ::....||  ::|||.|.|:|.|||||.|.|||.|:||||||||||||:||..|||||
  Rat  1467 RPVFSHENIQGGGEP--FQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFP 1529

  Fly  2562 GNYVER 2567
            ||||:|
  Rat  1530 GNYVKR 1535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	Sorb	1959..2003	CDD:470634	10/53 (19%)
		SH3_Sorbs_1	2315..2367	CDD:212715	32/51 (63%)
		SH3_Sorbs_2	2384..2436	CDD:212716	32/53 (60%)
		SH3_Sorbs_3	2514..2567	CDD:212714	39/52 (75%)
Sorbs2	XP_063131059.1	None