DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAP and SORBS1

DIOPT Version :9

Sequence 1:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster
Sequence 2:	NP_001371381.1	Gene:	SORBS1 / 10580	HGNCID:	14565	Length:	1628	Species:	Homo sapiens

Alignment Length:	1853	Identity:	375/1853 - (20%)
Similarity:	584/1853 - (31%)	Gaps:	755/1853 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1192 EFPSHQPVSQTKRYSNIETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIM 1256
            |.||..|.|..      ||..:|||..:|                              |.|...
Human    49 ETPSSSPASPQ------ETRQHESKPGLE------------------------------PEPSSA 77

  Fly  1257 SATKLNGNTFIDGDVAPKNSQPSRESGSGSGNGTYEEFR-----QRAKAAADAFGEQREQQNGLD 1316
            ...:|:.:...:|     |:|||..:..|     |....     .:::.::....|......|.|
Human    78 DEWRLSSSADANG-----NAQPSSLAAKG-----YRSVHPNLPSDKSQDSSPLLNEVSSSLIGTD 132

  Fly  1317 QDRVFKDFDRLSQQMHAE------------LQSTREKREKSASMYDLSGFTRPASGHPRLDELQQ 1369
            .    :.|..:|:...|.            ||..||::::.:|:.|      |.|..    .:.:
Human   133 S----QAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSD------PVSER----RVGE 183

  Fly  1370 RRHAHMQELE----REIERSAKSRQERMSSVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEP 1430
            :..|..||..    :.||:.||....|:  |....:.:.....|:.|.|....|..:.
Human   184 QDSAPTQEKPTSPGKAIEKRAKDDSRRV--VKSTQDLSDVSMDEVGIPLRNTERSKDW------- 239

  Fly  1431 PPRPHTTVGHYNHPVVQDDWS-RYANDLGYSENIARPFA---REVEICYQRQNQRTPHCIRAPRL 1491
                :.|:....|.:.:||.| .|:....:||:...|.:   .:.|:.|....:........| |
Human   240 ----YKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLP-L 299

  Fly  1492 SASTNDLSSSSQYSYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSR-- 1554
            .|.::.|.|||:           |....|  ...:...|.:.....|:.|..|....:.|..:
Human   300 PARSSSLKSSSE-----------RNDWEP--PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMS 351

  Fly  1555 RGVSP--------------------APPPVA----TPQQQQVPPPAYDRQQRRSSLPRELHEQQL 1595
            |.:||                    .|||..    ||....:.|    |:.|:::|.::|...|
Human   352 RDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILP----REDRKTNLDKDLSLCQ- 411

  Fly  1596 KYILSKEEELKFEVERLQQERRRLMEEMQRAP---------VLPAPQ-----------------R 1634
                   .||:.::|:        ||.:.:||         :.|.|:                 :
Human   412 -------TELEADLEK--------METLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVK 461

  Fly  1635 RESYRPAAKLPTLSEDEVFRQQMAE------EWMNKVAEREERRQHKIIR----ISKIEDEHDHS 1689
            |||......|.:|..:....:.:.|      :.::.:.........|:.|    ...|.....||
Human   462 RESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSVHS 526

  Fly  1690 -------------------AVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQSQP 1735
                               :..||.||:....:.|.|   ||.|:....|..:...|...|||..
Human   527 RTFNTSNALGPVCKHKKPLSAAKACISEILPSKFKPR---LSAPSALLQEQKSILLPSEKAQSCE 588

  Fly  1736 ESDVEAP--------PVRILEGQAEANLRQLPRHLREF----------AKFSTSEQLP------D 1776
            ...|...        |:::  |.:..||  |.|..|::          .::|||.:.|      .
Human   589 NLCVSGSLNDSKRGLPLQV--GGSIENL--LMRSRRDYDSKSSSTMSLQEYSTSGRRPCPLSRKA 649

  Fly  1777 GAQ---MERHEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRLYRE 1838
            |.|   :.|...|..|......:.||::....:...::.|.|..|             ||.|...
Human   650 GMQFTMLYRDMHQINRSGLFLGSISSSSSVRDLASHFEKSSLALS-------------RGELGPS 701

  Fly  1839 RSQTARLVSHNIPLELTS------NHSSSPDSDFNPGCGSSPAP----GSSTQS-SIPSLVQSPT 1892
            :..:..:..|.:...:|:      ...|.|..|.:.....||.|    ||.|.: |..||::| |
Human   702 QEGSEHIPKHTVSSRITAFEQLIQRSRSMPSLDLSGRLSKSPTPVLSRGSLTSARSAESLLES-T 765

  Fly  1893 PAPPPPIEPLNPS----SSTAGGILGTAL-LLGLSLLTAWNKFIYKVKHEYMSEP-ETGSDRPRK 1951
            ...|..::.:|.|    |.|...:...|| ..||                ..||| .|.||...:
Human   766 KLHPKEMDGMNSSGVYASPTCSNMAHHALSFRGL----------------VPSEPLSTCSDDVDR 814

  Fly  1952 MAQLGRRQYDGIGPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKNGDDFVIRYKCPRARPS 2016
            .:.:.....:|.|...:...|           :|.        ::|.|.        .||.
Human   815 CSNISTDSREGSGGSVHGDFP-----------KHR--------LNKCKG--------TCPA---- 848

  Fly  2017 YKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVS------------SAVNVRNLNQDEKLYGTM 2069
                              |..|:.|...|..|..|            .:..:||:    .|...:
Human   849 ------------------SYTRFTTIRKHEQQQTSRQPEWRLDARGDKSTLLRNI----YLMSPL 891

  Fly  2070 PNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMDIFNGNLEQSKLSPLYTEGNLSRA 2134
            |..:|...:.:..||                                      ||
Human   892 PFRLKKPLHHHPRQP--------------------------------------SP---------- 908

  Fly  2135 LAKESGYTSDSN--LVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPL---LGFR---------- 2184
                    .||:  ||.:|.::| |.|    .|.|.    .:||:|.:   |..|
Human   909 --------GDSSGLLVGQKPDLP-SQP----HQDQP----PSGGKPVVPTRLSSRHTMARLSRSS 956

  Fly  2185 KPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVD--------------GSDVNIHFKTPI 2235
            :|:.|:|..|:..     |:....|.|   .|||..::|              .|:...|| .|.
Human   957 EPSQERPTALEDY-----PRAINNGNS---VPYSDHSLDRNNNPQSELAPSRGDSESPRHF-IPA 1012

  Fly  2236 RHEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDD- 2299
            .:.:    |.||...|:.:..:||..::||.|..||..|:.:|||| ...|:....|...|:.|
Human  1013 DYLE----STEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHT-GVIPTHHQFITNERFGDL 1072

  Fly  2300 FPTDVTLKSLVGPK-TVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPAS 2363
            ...|.|.|...|.: ..|||.|:|:.||.|||..:|||.:||.:|||.|||||||:..:|:.|.:
Human  1073 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRT 1137

  Fly  2364 YVEIV-----SRDGARTPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI- 2422
            |:|::     ::....||.:....|:|.||:||...:.:|:|..|||.:||.|:||.||:||:|
Human  1138 YIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP 1202

  Fly  2423 -ANRKGIFPCSYVEVL------------------------------------------------- 2437
             .:|:||||.:||:|:
Human  1203 GTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPSSLPHSRR 1267

  Fly  2438 ------------------------------------------TD--------------------- 2439
                                                      ||
Human  1268 ALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSW 1332

  Fly  2440 --------------------------------------------------------IGAED-IAA 2447
                                                                    :|:.| :.:
Human  1333 SDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVIS 1397

  Fly  2448 RTTTVITSQSTTN--------------------------------LRPNLDVLRTNIN----NEF 2476
            :.:...:|||...                                |:|: ||:|....    ::.
Human  1398 QLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPS-DVVRCLSTEQRLSDL 1461

  Fly  2477 NTLTQNGAQPPNG---------------------------------ILKETRTLHKTDALHVDTS 2508
            ||..::....|.|                                 :..|...:.:....:..|.
Human  1462 NTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQEAVCNEIINIAEKSVHYCSTV 1526

  Fly  2509 SEPL----------------------------------------AYRALYKYRPQNSDELELLEG 2533
            |.||                                        :|:|||.|.|||.|||||.:|
Human  1527 SHPLDFHHKVSPSDNKSSLIISQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 1591

  Fly  2534 DVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVE 2566
            |:|.|:||||||||||||:||..|||||||||:
Human  1592 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	6/43 (14%)
		SH3_Sorbs_1	2315..2367	CDD:212715	28/51 (55%)
		SH3_Sorbs_2	2384..2436	CDD:212716	27/53 (51%)
		SH3_Sorbs_3	2514..2567	CDD:212714	40/53 (75%)
SORBS1	NP_001371381.1	Sorb	215..256	CDD:396678	8/51 (16%)
		SH3_Sorbs1_1	1088..1142	CDD:212852	29/53 (55%)
		SH3_Sorbs1_2	1162..1219	CDD:212855	29/56 (52%)
		SH3_Sorbs1_3	1569..1627	CDD:212849	40/56 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7841
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2748
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004115
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106599
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860