DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAP and SORBS3

DIOPT Version :9

Sequence 1:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster
Sequence 2:	XP_006716329.1	Gene:	SORBS3 / 10174	HGNCID:	30907	Length:	710	Species:	Homo sapiens

Alignment Length:	880	Identity:	243/880 - (27%)
Similarity:	344/880 - (39%)	Gaps:	262/880 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1773 QLPDGAQMERHEEQERREEA-----------TDNAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQ 1826
            ::|...:.......|::||:           .|..|  |.::.:..::   |.|.||:||.
Human     3 RIPGVGRASASPSWEKKEESESDVVLLSPKDPDRGH--AEEQLACPES---SHLDPSMQGP---- 58

  Fly  1827 FSGGNRGRLYRERSQTARL-VSHNIPLELTSN-HSSSPDSDFNPGCGSSPAPGS----------- 1878
                       .||..|.| :...||..|.|: .|||..:.|:     .|||.:
Human    59 -----------PRSLRAGLSLDDFIPGHLQSHIGSSSRGTRFH-----DPAPRTVCNGGYTPRRD 107

  Fly  1879 STQSSIPSLVQS-PTPAPPPPIEPLNPSSSTAGGILGTALLLGLSLLTAWNKFIYKVKHEYMSEP 1942
            ::|...|:..|: |.|...|......|:|........|           |.|
Human   108 ASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSAT-----------WTK------------- 148

  Fly  1943 ETGSDRPRKMAQLGRR--QYDGIGPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKNGDDFV 2005
                |..|:    .:|  :|:|||||...||||..||.|..|  .:||:|::|.||
Human   149 ----DSKRR----DKRWVKYEGIGPVDESGMPIAPRSSVDRP--RDWYRRMFQQIH--------- 194

  Fly  2006 IRYKCPRARPSYKSNGYVSEP--EPNYDSDYSTVRYRTQNP-HRVQSVSSAVNVRNLNQDEKLYG 2067
                  |..|..:.:....||  :|.:..       ..|.| ||....:|: :.|:.:..|:|
Human   195 ------RKMPDLQLDWTFEEPPRDPRHLG-------AQQRPAHRPGPATSS-SGRSWDHSEEL-- 243

  Fly  2068 TMPNPIKSAQNSYKNQPGRIENYTTGHSSV---SEKEKKEWWDEVMDIFNGNLE--QSKLSPLYT 2127
                    .::::..:||.........:.|   .||....|.:|..:.|...||  |....||..
Human   244 --------PRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVD 300

  Fly  2128 EGN----------LSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLG 2182
            :..          |.|.||:.|. ..|.:|  |..|..:.||.|....::|.:.....|  |...
Human   301 DPGEKPSQPIEVLLERELAELSA-ELDKDL--RAIETRLPSPKSSPAPRRAPEQRPPAG--PASA 360

  Fly  2183 FRKPAPEKP-----RDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQN 2242
            :....|..|     |.|.|:.......|   .|...||.|.:.|.|.|..| ...:|.|
Human   361 WSSSYPHAPYLGSARSLSPHKMADGGSP---FLGRRDFVYPSSTRDPSASN-GGGSPAR------ 415

  Fly  2243 LSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLK 2307
                              .||::||
Human   416 ------------------REEKKRK---------------------------------------- 422

  Fly  2308 SLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDG 2372
                   .||..|:||.|:.|||:.:|||.:||.:::|.||.||||:..:|:.||:|||::..|.
Human   423 -------AARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADE 480

  Fly  2373 ARTPSKRPS-----EGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI--ANRKGIFP 2430
            ...|.|.|:     .|:|.|:|.|:....:|||..|||.:.|.|:|:.||:||:|  ..|:||||
Human   481 IPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFP 545

  Fly  2431 CSYVEV-------LTDIGAE-DIAARTTTVITS----QSTTNLRPNLDVL---------RTNIN- 2473
            .|||:|       |.|.|.: ..:.|.|....|    .|.:.||...|.:         ||..:
Human   546 ASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSF 610

  Fly  2474 --NEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLA------YRALYKYRPQNSDELEL 2530
              .|....|||...|...:.......|..|   :.|||...:      |||:|:|||||.|||||
Human   611 PTQEPRPQTQNLGTPGPALSHSRGPSHPLD---LGTSSPNTSQIHWTPYRAMYQYRPQNEDELEL 672

  Fly  2531 LEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYV 2565
            .|||.|.|:::||||||||.|:||..|||||||||
Human   673 REGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	20/43 (47%)
		SH3_Sorbs_1	2315..2367	CDD:212715	26/51 (51%)
		SH3_Sorbs_2	2384..2436	CDD:212716	26/53 (49%)
		SH3_Sorbs_3	2514..2567	CDD:212714	39/52 (75%)
SORBS3	XP_006716329.1	Sorb	155..204	CDD:128735	23/65 (35%)
		AC_N	337..>412	CDD:292831	20/80 (25%)
		SH3_Vinexin_1	422..476	CDD:212854	28/100 (28%)
		SH3_Vinexin_2	496..551	CDD:212857	27/54 (50%)
		SH3_Vinexin_3	653..710	CDD:212851	39/55 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7841
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004115
OrthoInspector	1	1.000	-	-		otm40780
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8484
SonicParanoid	1	1.000	-	-		X3387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.940