Protein Alignment Hdc and SGPL1

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: NP_001425282.1
• Gene: SGPL1 / 8879
• HGNCID: 10817
• Length: 579
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 105/568 - (18%)
• Similarity: 198/568 - (34%)
• Gaps: 138/568 - (24%)

  Fly    10 GKEMVDYIADYLENIRERRVFPDVSPGYMRQL----LPESAPIEG-EPWPKIFSDVERIVMPGIT 69
            |:::.|.:....::|.:...|..|...|::.|    |..||.:|. :.:..:.|....|:.....
Human    85 GRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMASPDVNILYNHDA 149

  Fly    70 HWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASS------PACTELEIIVMNWLGKMI-G 127
            .||......   .:.|....|.::|..|..  .|.|::.      |...::|..::.....:. |
Human   150 FWQEGRASG---TVYSGEEKLTELLVKAYG--DFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNG 209

  Fly   128 LPDAFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQA 192
            .||:.          |.:.:..:|:.|:...|.|..|.::      |.:..||.|      ...|
Human   210 GPDSC----------GCVTSGGTESILMACKAYRDLAFEK------GIKTPEIVA------PQSA 252

  Fly   193 HSSVEKAA--------LIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCAT----LG 245
            |::..|||        .:.|.:|..::.        :.:|.||..:     ....||:|    .|
Human   253 HAAFNKAASYFGMKIVRVPLTKMMEVDV--------RAMRRAISRN-----TAMLVCSTPQFPHG 304

  Fly   246 TTGSCSFDNLEEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHF 310
            .     .|.:.|:..:..::.:.|||||...|...:.         :|:|.....:|       |
Human   305 V-----IDPVPEVAKLAVKYKIPLHVDACLGGFLIVF---------MEKAGYPLEHP-------F 348

  Fly   311 DATALWVRDSTAVHRTFNVEP------LY--LQHENSGVAVDFMHWQ-----IPLSRRFR----A 358
            |.....|...:|....:...|      ||  .::.|....|| ..||     .|.....|    :
Human   349 DFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVD-TDWQGGIYASPTIAGSRPGGIS 412

  Fly   359 LKVWFVLRSYGIKGLQRHIREGVRLAQKFEA--------LVLADHRFELPAKRHLGLVVFRIRGD 415
            ...|..|..:|..|.....::.::.|:..::        .|..:.:..:.|.......::|:  .
Human   413 AACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRL--S 475

  Fly   416 NEITEK--LLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTTLDDIVKDWMEIRQVASTVLE--E 476
            |.:|.|  .|.:|....::|             |.||..|......::...:||:..:.:::  :
Human   476 NLMTAKGWNLNQLQFPPSIH-------------FCITLLHARKRVAIQFLKDIRESVTQIMKNPK 527

  Fly   477 MNITISNRVY--LKETKEKN------EAFGSSLLLSNSPLSPKVVNGS 516
            ...|....:|  .:.|.::|      ..|..||..:::......:|||
Human   528 AKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGS 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	78/426 (18%)
SGPL1	NP_001425282.1	None