Protein Alignment Hdc and GAD1

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: NP_013976.1
• Gene: GAD1 / 855291
• SGDID: S000004862
• Length: 585
• Species: Saccharomyces cerevisiae
• Alignment Length: 542
• Identity: 115/542 - (21%)
• Similarity: 192/542 - (35%)
• Gaps: 171/542 - (31%)

  Fly   134 HLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSVEK 198
            |.:...:..|...|.:|||.::..||.:.|...|.  ::.|...::.|..:.:.|    ..::||
Yeast   139 HANPDEEPIGCATTGSSEAIMLGGLAMKKRWEHRM--KNAGKDASKPNIIMSSAC----QVALEK 197

  Fly   199 AALIGLVRMRYIEADDDLA-----MRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEI 258
            ..       ||.|.:..|.     ....|..|::.|.:.:..:..:|  .||||.:...:|:|::
Yeast   198 FT-------RYFEVECRLVPVSHRSHHMLDPESLWDYVDENTIGCFV--ILGTTYTGHLENVEKV 253

  Fly   259 GIVC----AEHHLW------LHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVH---- 309
            ..|.    |:|..|      :|.|.|..|  ||.|      .|.|:....|:...:|...|
Yeast   254 ADVLSQIEAKHPDWSNTDIPIHADGASGG--FIIP------FGFEKEHMKAYGMERWGFNHPRVV 310

  Fly   310 --------FDAT------ALWVRDSTAVHRTFNVEPLYLQHENSGVAVDF-MHWQIPLSRRFRAL 359
                    |..|      .|| ||.:.:......:..||    .||...| :::..|   .|:.:
Yeast   311 SMNTSGHKFGLTTPGLGWVLW-RDESLLADELRFKLKYL----GGVEETFGLNFSRP---GFQVV 367

  Fly   360 KVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLK 424
            ..:|...|.|..|.:...:..:.:|:.|.        |||
Yeast   368 HQYFNFVSLGHSGYRTQFQNSLFVARAFS--------FEL------------------------- 399

  Fly   425 RLNHRGNLHCIPSSLKGQYVIRFTITSTHTTLDD-----IVKDWMEIRQVASTVLEEMNITISNR 484
             ||        .|.|.|.:.|   ::|.|.::::     .|||:.|..|.....:..:...:|.:
Yeast   400 -LN--------SSKLPGCFEI---VSSIHESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLSKK 452

  Fly   485 VYLKETKEKNEAFGSSLL------LSNSPLSPKVVNGSFAAIFDADEFLAKTYAGVRIAHQESPS 543
            .: :|..|..:|..||||      :.|.|| ||..:||     |..|.|
Yeast   453 FH-EEYPEVPQAILSSLLRGRGWIIPNYPL-PKATDGS-----DEKEVL---------------- 494

  Fly   544 MRRRVRGILMSGKQFSLDSHMDVVVQTTLDAGNGATRTSTTNSY----GHTTSAAQANSERQASI 604
                 |.:..|..:..|...:.|.:::.|        |...:||    .|...|::...||::|.
Yeast   495 -----RVVFRSEMKLDLAQLLIVDIESIL--------TKLIHSYEKVCHHIELASEQTPERKSSF 546

  Fly   605 ----------QEDNEESPEETE 616
                      .:|:..:|:|.|
Yeast   547 IYEMLLALASPQDDIPTPDEIE 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	67/312 (21%)
GAD1	NP_013976.1	Glu-decarb-GAD	41..522	CDD:130848	104/494 (21%)