DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdc and AAS

DIOPT Version :9

Sequence 1:	NP_001260855.1	Gene:	Hdc / 36076	FlyBaseID:	FBgn0005619	Length:	847	Species:	Drosophila melanogaster
Sequence 2:	NP_849999.1	Gene:	AAS / 816553	AraportID:	AT2G20340	Length:	490	Species:	Arabidopsis thaliana

Alignment Length:	490	Identity:	194/490 - (39%)
Similarity:	298/490 - (60%)	Gaps:	25/490 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVM 65
            ||.::.|:.|..|||:||||.:.|.:..|...|.|||:.:|||:|||...|...::..||...::
plant    12 MDSEQLREYGHLMVDFIADYYKTIEDFPVLSQVQPGYLHKLLPDSAPDHPETLDQVLDDVRAKIL 76

  Fly    66 PGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPD 130
            ||:||||||...||:|:.:|:...||:||:..:..:||:|.:|||.||||:||::|:.|::.||:
plant    77 PGVTHWQSPSFFAYYPSNSSVAGFLGEMLSAGLGIVGFSWVTSPAATELEMIVLDWVAKLLNLPE 141

  Fly   131 AFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSS 195
            .|:   |:..||||:|.:||||.||.|:|.|.:.:     |..|....|   :||.|.|||.||:
plant   142 QFM---SKGNGGGVIQGSASEAVLVVLIAARDKVL-----RSVGKNALE---KLVVYSSDQTHSA 195

  Fly   196 VEKAALIGLV-----RMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNL 255
            ::||..|..:     |:...::..:.|:|.:.|:||:..|::.||:||::||.:|||.|.:.|.|
plant   196 LQKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSRDLEAGLIPFFLCANVGTTSSTAVDPL 260

  Fly   256 EEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDS 320
            ..:|.:...:.:|.||||||||||.||||:|.::.|:|.|||...|..||.:.:||.:.|||:|.
plant   261 AALGKIANSNGIWFHVDAAYAGSACICPEYRQYIDGVETADSFNMNAHKWFLTNFDCSLLWVKDQ 325

  Fly   321 TAVHRTFNVEPLYLQHENS--GVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRL 383
            .::....:..|.:|:::.|  .:.||:..|||||.||||:||:|.|||.||.:.|:.:||..::|
plant   326 DSLTLALSTNPEFLKNKASQANLVVDYKDWQIPLGRRFRSLKLWMVLRLYGSETLKSYIRNHIKL 390

  Fly   384 AQKFEALVLADHRFELPAKRHLGLVVFRI-------RGDNEITEKLLKRLNHRGNLHCIPSSLKG 441
            |::||.||..|..||:...|...||.||:       :..|....:||..:|..|.|....::|.|
plant   391 AKEFEQLVSQDPNFEIVTPRIFALVCFRLVPVKDEEKKCNNRNRELLDAVNSSGKLFMSHTALSG 455

  Fly   442 QYVIRFTITSTHTTLDDIVKDWMEIRQVASTVLEE 476
            :.|:|..|.:..|....:.:.|..|::.||.:|.:
plant   456 KIVLRCAIGAPLTEEKHVKEAWKIIQEEASYLLHK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	163/391 (42%)
AAS	NP_849999.1	PLN02880	3..490	CDD:215475	194/488 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	368	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I444
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D856958at2759
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		mtm1068
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	O	PTHR11999
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840