Protein Alignment Hdc and Gadl1

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: NP_001382689.1
• Gene: Gadl1 / 73748
• MGIID: 1920998
• Length: 522
• Species: Mus musculus
• Alignment Length: 553
• Identity: 143/553 - (25%)
• Similarity: 231/553 - (41%)
• Gaps: 125/553 - (22%)

  Fly    11 KEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGITHWQSPH 75
            :|:|....|..|.:.|.:     .|..:||||.......||...|:....:.::     |:....
Mouse    59 EEVVLKATDVNEKVCEWQ-----PPEQLRQLLDLEMRDTGESQDKLLKLCQDVI-----HFSVKT 113

  Fly    76 MHAYFPALNSM------PSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLH 134
            .|..|  .|.:      .||...::.:|:|...:|:..||....:|..|:..:.:.:|
Mouse   114 NHPRF--FNQLYAGLDYYSLAARIITEALNPSIYTYEVSPVFLLVEEAVLKKMIECVG------- 169

  Fly   135 LSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERH-PGYQDAEINA--RLVAYCSDQAHSSV 196
               ..:|.|:.....|.:.:..:...|        .|| |..::..::.  ||:.:.|.:.|.|:
Mouse   170 ---WKEGDGIFNPGGSVSNMCAMNLAR--------YRHCPDIKEKGLSGLPRLILFTSAECHYSM 223

  Fly   197 EKAAL---IGLVRMRYIEADDDLAMRGKLLREAIEDDI----KQGLVPFWVCATLGTTGSCSFDN 254
            :|||.   ||...:.::|.|.    |||::.|.:|..|    ::|.|||.||||.|||...:||.
Mouse   224 KKAASFLGIGTQNVYFVETDG----RGKMIPEDLEKQIWQARQEGAVPFLVCATSGTTVLGAFDP 284

  Fly   255 LEEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRD 319
            |:||..||..|.|||||||::.|||.:..:.|..|.||.||||:|:||.|.||.....:||.|:|
Mouse   285 LDEIAEVCERHGLWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKD 349

  Fly   320 -STAVHRTFNVEPLYL--QHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGV 381
             |..:.:.::.:..||  |.:...|:.|.....|..|||..|.|.|...::.|..||:..:....
Mouse   350 KSDLLKKCYSAKATYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTSGLEERVNRAF 414

  Fly   382 RLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHC---IPSSLKGQY 443
            .|::     .|.|.     .|:..|   |::..:.|.|..            |   ||.||:
Mouse   415 ALSR-----YLVDE-----IKKREG---FKLLMEPEYTNV------------CFWYIPPSLR--- 451

  Fly   444 VIRFTITSTHTTLDDIVKDWMEIRQVASTVLEEMNITISNRVYLKETKEKNEAFGSSLLLSNSP- 507
                       .:::..:.|.::..||..:.|:|         :|:         .||:|...|
Mouse   452 -----------EMEEGPEFWRKLSLVAPAIKEKM---------MKK---------GSLMLGYQPH 487

  Fly   508 -----------LSPKVVNGSFAAIFDADEFLAK 529
                       :||:|.......:.|..:.|.:
Mouse   488 RGKVNFFRQVVISPQVSREDMDFLLDEIDSLGR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	116/396 (29%)
Gadl1	NP_001382689.1	GadA	76..521	CDD:439846	138/536 (26%)