Protein Alignment Hdc and CSAD

DIOPT Version :9

• Sequence 1: NP_001260855.1
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: XP_024304779.1
• Gene: CSAD / 51380
• HGNCID: 18966
• Length: 620
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 119/521 - (22%)
• Similarity: 200/521 - (38%)
• Gaps: 113/521 - (21%)

  Fly     8 QRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGITHWQ 72
            |:|..:...:.::.|            |..::|||......:||...:|......::...:....
Human   130 QKGTSVSQKVCEWKE------------PEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGH 182

  Fly    73 SPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLHLSS 137
            ....:..|..|:. .:|.|.::.:::|...:|:..:|....:|..|:..|..::|
Human   183 PRFFNQLFSGLDP-HALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVG---------- 236

  Fly   138 QSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSVEKAALI 202
            .|.|.|:.....|.:.:..:...|       ::|:|.             |..:...::...||.
Human   237 WSSGDGIFCPGGSISNMYAVNLAR-------YQRYPD-------------CKQRGLRTLPPLALF 281

  Fly   203 -------------GLV-------------RMRYIEADDDLAMRGKLLREA--------------- 226
                         ||:             .:|:.:....::...:|:||.
Human   282 TSKEVGKRHRPNPGLLILISSHVTTPSRRELRFWDLAPTVSEWSRLMREGKWSPRIWRGRLVWPR 346

  Fly   227 -------IEDDI-KQGLVPFWVCATLGTTGSCSFDNLEEIGIVCAEHHLWLHVDAAYAGSAFICP 283
                   .|..| ..|.|||.|.||.|||...:||.||.|..||..|.||||||||:.||..:..
Human   347 LRLTFHFFETFILDSGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQ 411

  Fly   284 EFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRD-STAVHRTFNVEPLYL--QHENSGVAVDF 345
            ..|..|.||:||||:|:||.|.|......:||.::| |..:.|....:..||  |.:...||:|.
Human   412 THRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDT 476

  Fly   346 MHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVF 410
            ....:...||...||:|.:.::.|.:||:|.|.:...||:.....:.....|||..:.....|.|
Human   477 GDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCF 541

  Fly   411 -----RIRGDNE----------ITEKLLKRLNHRGNLHC--IPSSLKGQYVIRFTITSTHTTLDD 458
                 .:||..|          :...|.:|:...|::..  .|...:|.: .|..:.::..|..|
Human   542 WFVPPSLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNF-FRVVVANSALTCAD 605

  Fly   459 I 459
            :
Human   606 M 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	105/434 (24%)
CSAD	XP_024304779.1	DOPA_deC_like	185..616	CDD:99743	109/454 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810