Protein Alignment Hdc and GADL1

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: NP_997242.2
• Gene: GADL1 / 339896
• HGNCID: 27949
• Length: 521
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 144/550 - (26%)
• Similarity: 227/550 - (41%)
• Gaps: 119/550 - (21%)

  Fly    11 KEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGITHWQSPH 75
            :|:|....|..|.:.|.|     .|..::|||.......|||..|:..     :...:.|:....
Human    58 EEVVLKATDVNEKVCEWR-----PPEQLKQLLDLEMRDSGEPPHKLLE-----LCRDVIHYSVKT 112

  Fly    76 MHAYFPALNSM------PSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLH 134
            .|..|  .|.:      .||:...:.:|:|...:|:..||....:|..|:..:.:.||
Human   113 NHPRF--FNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIG------- 168

  Fly   135 LSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSVEKA 199
               ..:|.|:.....|.:.:..:...|.:......|:  |...   :.||:.:.|.:.|.|::||
Human   169 ---WKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEK--GLSG---SPRLILFTSAECHYSMKKA 225

  Fly   200 AL---IGLVRMRYIEADDDLAMRGKLLREAIEDDI----KQGLVPFWVCATLGTTGSCSFDNLEE 257
            |.   ||...:.::|.|.    |||::.|.:|..:    |:|..||.||||.|||...:||.|:|
Human   226 ASFLGIGTENVCFVETDG----RGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDE 286

  Fly   258 IGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRD-ST 321
            |..:|..|.|||||||::.|||.:..:.|..|.||.||||:|:||.|.||......||.|:| |.
Human   287 IADICERHSLWLHVDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSD 351

  Fly   322 AVHRTFNVEPLYL--QHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLA 384
            .:.:.::.:..||  |.:...|:.|.....|..|||..|.|.|...::.|..||:..:...:.|:
Human   352 LLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALS 416

  Fly   385 QKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHC---IPSSLKGQYVIR 446
            :     .|.|.     .|:..|.             |||....: .|: |   ||.||:
Human   417 R-----YLVDE-----IKKREGF-------------KLLMEPEY-ANI-CFWYIPPSLR------ 450

  Fly   447 FTITSTHTTLDDIVKDWMEIRQVASTVLEEMNITISNRVYLKETKEKNEAFGSSLLLSNSP---- 507
                    .:::..:.|.::..||..:.|.|         :|:         .||:|...|
Human   451 --------EMEEGPEFWAKLNLVAPAIKERM---------MKK---------GSLMLGYQPHRGK 489

  Fly   508 --------LSPKVVNGSFAAIFDADEFLAK 529
                    :||:|.......:.|..:.|.|
Human   490 VNFFRQVVISPQVSREDMDFLLDEIDLLGK 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	113/393 (29%)
GADL1	NP_997242.2	GadA	75..520	CDD:439846	138/532 (26%)