Protein Alignment Hdc and HDC

DIOPT Version :9

• Sequence 1: NP_001260855.1
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 294/511 - (57%)
• Similarity: 373/511 - (72%)
• Gaps: 35/511 - (6%)

  Fly     1 MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVM 65
            |:.:|||:||:||||||..||..:|||||.|||.|||:|..||||||.:.:.|..||.|:|||:|
Human     2 MEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIM 66

  Fly    66 PGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPD 130
            ||:.||||||||||:|||.|.|||||||||||||||||||||||||||||:.||:||.||:|||:
Human    67 PGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPE 131

  Fly   131 AFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSS 195
            .|||....||||||||:|.||:||:.|||.|...|.......|...::.:|||||||.|||||||
Human   132 HFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSS 196

  Fly   196 VEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGI 260
            ||||.||.||:|:::..||:.::||:.|::|||:|.::||||.:|||||||||.|:||.|.|:|.
Human   197 VEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGP 261

  Fly   261 VCAEHH-----------------------------------LWLHVDAAYAGSAFICPEFRTWLR 290
            :...||                                   ||||:||||||:||:|||||.:|:
Human   262 ISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPEFRGFLK 326

  Fly   291 GIERADSIAFNPSKWLMVHFDATALWVRDSTAVHRTFNVEPLYLQHENSGVAVDFMHWQIPLSRR 355
            |||.|||..||||||:|||||.|..||:|...:.:||:|.|:||:|.|||||.||||||||||||
Human   327 GIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRR 391

  Fly   356 FRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITE 420
            ||::|:|||:||:|:|.||.|:|.|..:|:.||:||..|..||:||||||||||||::|.|.:||
Human   392 FRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTE 456

  Fly   421 KLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTTLDDIVKDWMEIRQVASTVLEE 476
            .:||.:...|.|..||::::.:.:||||:||..||.|||::||..||..|:.:|.:
Human   457 NVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQ 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	245/412 (59%)
HDC	XP_016877583.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158059
Domainoid	1	1.000	531	1.000	Domainoid score	I278
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20490
Inparanoid	1	1.050	635	1.000	Inparanoid score	I834
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		oto90928
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	LDO	PTHR11999
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9928
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800