Protein Alignment Hdc and Tdc2

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 290/612 - (47%)
• Similarity: 387/612 - (63%)
• Gaps: 50/612 - (8%)

  Fly     1 MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVM 65
            ||..|:|:||.|||:||.:|||.:.||||.|.|.|||:|.|||..||.|.|.|.:|..|||..:|
  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65

  Fly    66 PGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPD 130
            ||:||||.|..||||||.||.||:|||||.|.|.|:||:||:||||||||.||::||||.|||||
  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130

  Fly   131 AFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSS 195
            .||.|...|.||||:||:|||..||.:||.|.:|::|...:||..::..:.::|:||||.:|||.
  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSC 195

  Fly   196 VEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGI 260
            |||||:|..|::|.:|.|||.::||:.:.||:|:|..||||||:|..||||||||:||||.|||.
  Fly   196 VEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGK 260

  Fly   261 VCAEH-HLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVH 324
            ..... .:||||||||||::|||||.:..|:|||.|||...||:|||:.:||.:.|||||...:.
  Fly   261 QLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRIRLT 325

  Fly   325 RTFNVEPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEA 389
            ....|:||||:|..|..|:|:.||.:|||||||:||:|||||||||.|||.:||..::||::||.
  Fly   326 SALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKRFEE 390

  Fly   390 LVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHT 454
            |||.|.|||:..:..||||.||::|.:::.||||..:|..|.||.:|:|:..:|:|||...:.:.
  Fly   391 LVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVAQNA 455

  Fly   455 TLDDIVKDWMEIRQVASTVLE-----EMNITISNRVYLKETKEKNEAF----------------- 497
            |.:||...|..|...|:.:||     |:: .|.||.......:|...|
  Fly   456 TAEDIDYAWDIIVDFANELLEKEQHDELS-EIMNRKKQDTLAQKRSFFVRMVSDPKIYNPAINKA 519

  Fly   498 GSSLLLSNSPLSPKVVNGS-------------------FAAIFDADEFLAKTYAGVRIAHQES-- 541
            |:..|....| ||.|..||                   .|.:|:::.....:...:|..|.::
  Fly   520 GTPKLSMELP-SPVVSRGSAPIIRTQSSVDHNSWISWPLAFLFNSNNEEKGSNVSLRFRHLDTNV 583

  Fly   542 -PSMRRRVRGILMSGKQFSLDSHMDVV 567
             ||..||..|   :|...|.::.:|.|
  Fly   584 RPSSSRRNSG---AGSSPSPENELDYV 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	220/378 (58%)
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:395219	220/378 (58%)