DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdc and Hdc

DIOPT Version :9

Sequence 1:	NP_001260855.1	Gene:	Hdc / 36076	FlyBaseID:	FBgn0005619	Length:	847	Species:	Drosophila melanogaster
Sequence 2:	NP_058712.2	Gene:	Hdc / 24443	RGDID:	2790	Length:	656	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	288/475 - (60%)
Similarity:	372/475 - (78%)	Gaps:	0/475 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMP 66
            :::||:.|||||||||..||..:|||:|.|:|.|||:|..:|.|||.|.:.|..||.|:|:|:||
  Rat     6 EYREYQARGKEMVDYICQYLSTLRERQVTPNVKPGYLRAQIPSSAPEEPDSWDSIFGDIEQIIMP 70

  Fly    67 GITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDA 131
            |:.||||||||||:|||.|.|||||||||||||||||||||||||||||:.:|:||.||:||||.
  Rat    71 GVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLGLPDF 135

  Fly   132 FLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSV 196
            |||....||||||||:|.||:||:.|||.|...|.......|...::.:|||||||.||||||||
  Rat   136 FLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKAHEPNADESSLNARLVAYASDQAHSSV 200

  Fly   197 EKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGIV 261
            |||.||.||:::::..||:.::||:.|::|||:|.:|||||.:|||||||||.|:||.|.|:|.:
  Rat   201 EKAGLISLVKIKFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDKLSELGPI 265

  Fly   262 CAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVHRT 326
            ||...|||||||||||:||:|||.|.:|:|||.|||..||||||:|||||.|..||:|...:.:|
  Rat   266 CAREGLWLHVDAAYAGTAFLCPELRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQT 330

  Fly   327 FNVEPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALV 391
            |:|.|:||:|.|||||.||||||||||||||::|:|||:||:|:|.||.|:|.|..:|:.||:||
  Rat   331 FSVNPIYLRHANSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTDMAKYFESLV 395

  Fly   392 LADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTTL 456
            .:|..||:||:|||||||||::|.|.:||.:||.:...|.:..||::::.:.:||||:||..||.
  Rat   396 RSDPVFEIPAERHLGLVVFRLKGPNCLTESVLKEIAKTGQVFLIPATIQDKLIIRFTVTSQFTTK 460

  Fly   457 DDIVKDWMEIRQVASTVLEE 476
            |||::||..||:.|:.||.:
  Rat   461 DDILRDWNLIREAANLVLSQ 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	242/377 (64%)
Hdc	NP_058712.2	Pyridoxal_deC	39..417	CDD:278699	242/377 (64%)
Hdc	NP_058712.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..502		288/475 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352042
Domainoid	1	1.000	524	1.000	Domainoid score	I286
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20490
Inparanoid	1	1.050	623	1.000	Inparanoid score	I834
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		oto98024
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	LDO	PTHR11999
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910