DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdc and Ddc

DIOPT Version :9

Sequence 1:	NP_001260855.1	Gene:	Hdc / 36076	FlyBaseID:	FBgn0005619	Length:	847	Species:	Drosophila melanogaster
Sequence 2:	NP_001257781.1	Gene:	Ddc / 24311	RGDID:	2494	Length:	480	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	258/481 - (53%)
Similarity:	347/481 - (72%)	Gaps:	13/481 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVM 65
            ||.:|:|:|||||||||||||:.|..|.|:|||.|||:|.|:|.:||.|.|.:..|..|:|:|:|
  Rat     1 MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRALIPTTAPQEPETYEDIIRDIEKIIM 65

  Fly    66 PGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPD 130
            ||:|||.||:..||||..:|.|::|.|||..||.|:||:||:||||||||.::|:|||||:.||:
  Rat    66 PGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPE 130

  Fly   131 AFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSS 195
            ||| .....:||||:|.:|||||||.|||.||:.|::.....|....|.:..:||||.|||||||
  Rat   131 AFL-AGRAGEGGGVIQGSASEATLVALLAARTKMIRQLQAASPELTQAALMEKLVAYTSDQAHSS 194

  Fly   196 VEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGI 260
            ||:|.|||.|:::.|.:|.:.:||...||||:|.|...||:||:|..|||||..||||||.|:|.
  Rat   195 VERAGLIGGVKIKAIPSDGNYSMRAAALREALERDKAAGLIPFFVVVTLGTTSCCSFDNLLEVGP 259

  Fly   261 VCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVHR 325
            :|.:..:|||:|||||||||||||||..|.|:|.|||..|||.|||:|:||.:|:||:..|.:..
  Rat   260 ICNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTE 324

  Fly   326 TFNVEPLYLQ--HENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFE 388
            .||::|:||:  |::||:..|:.||||||.||||:||:|||.|.||:||||.:||:.|:|:.:||
  Rat   325 AFNMDPVYLRHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVKLSHEFE 389

  Fly   389 ALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRF-----T 448
            :||..|.|||:..:..||||.||::|.|::.|.||:|:|....:|.:|..|:.::|:||     |
  Rat   390 SLVRQDPRFEICTEVILGLVCFRLKGSNQLNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCSRT 454

  Fly   449 ITSTHTTLDDIVKDWMEIRQVASTVL 474
            :.|.|..|     .|..||.:||:||
  Rat   455 VESAHVQL-----AWEHIRDLASSVL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	211/379 (56%)
Ddc	NP_001257781.1	Pyridoxal_deC	35..414	CDD:278699	211/379 (56%)
Ddc	NP_001257781.1	2 X approximate tandem repeats	58..178		66/120 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11225
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730