Protein Alignment Hdc and hdl-2

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: NP_501539.3
• Gene: hdl-2 / 182464
• WormBaseID: WBGene00006409
• Length: 611
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 122/510 - (23%)
• Similarity: 219/510 - (42%)
• Gaps: 80/510 - (15%)

  Fly    13 MVDYIADYLENIRERRVFP--DVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGITHWQSPH 75
            :|.:|.||.:...::.|.|  ||:...:...:||.|    |...:|..|::.||:|.|.|...|.
 Worm   126 VVQFINDYFDESHKQPVIPENDVNSSRIHVKVPEKA----EELTEILKDLKEIVIPNICHTHHPR 186

  Fly    76 MHAYFPALNSMPSLLGDMLADAIN-CLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLHLSSQS 139
            .||.|...:     |.|::|..|: .||....|||....:|.|:..||...:.:|.....|....
 Worm   187 YHAKFAGKS-----LADLVASTISAALGHDVNSSPIIESIERIICKWLSTSMAIPQIKSSLGELR 246

  Fly   140 QGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSVEKAALIGL 204
            ...|.:..|..:..:..:    ..||::|.:...|.:.:: ||..:.||||.:...:::..:...
 Worm   247 DPIGTVFYTPCDVFISVI----RHAIEKFEKTDSGKERSK-NADYIVYCSDDSQVPLKEPCISCR 306

  Fly   205 VRMRYIEADD--DLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGIVCAEHHL 267
            |::|.:..|:  ...|....|.:.:|.||.:|..|..:.|..|:....:.|.:.::..|.....:
 Worm   307 VKLRKVITDEKNGSGMTSANLLKQMEKDIARGFTPLVIIANYGSANIAANDEIWDLVTVSRSKKI 371

  Fly   268 WLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLM-----VHFDATALWVRDSTAVHRTF 327
            |||:||:|||    |    .||      ||.:.|....|:     ||...::|:.. |..:...:
 Worm   372 WLHLDASYAG----C----EWL------DSNSRNNVHALISEVHSVHITCSSLFPY-SGRISVVW 421

  Fly   328 NVEPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKF-EALV 391
            :.|.|.|.      ....::.:.|       :::|.::|.:||:.::..::..:.|...| |.:.
 Worm   422 SCEKLELD------GAKILYGEHP-------IRLWILIRLHGIRSIREAVKRKIILGNAFSERMS 473

  Fly   392 LADHRFELPAKRHLGLVVF-----RIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITS 451
            .....||:......|:.||     :|:...|.|.|:....:   |...:.|:||      |:|.|
 Worm   474 HHSQLFEMHHTNEHGVTVFQYKNKKIKDRTEDTNKITSMFH---NYLVLSSTLK------FSIVS 529

  Fly   452 THTTLDDIVKDWMEIRQVASTVLEEMNITISNRV-----YLKETKE------KNE 495
            .|..:  ::|..:...:...::::|...|:.|.|     .||:.|:      |||
 Worm   530 FHGKV--LIKSVVNYGRCNLSIMDESVSTLVNSVDEFEEALKKKKKIVCETPKNE 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	91/391 (23%)
hdl-2	NP_501539.3	AAT_I	125..527	CDD:450240	108/451 (24%)