Protein Alignment Hdc and tdc-1

DIOPT Version :9

• Sequence 1: NP_001260855.1
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: NP_495743.1
• Gene: tdc-1 / 174327
• WormBaseID: WBGene00006562
• Length: 705
• Species: Caenorhabditis elegans
• Alignment Length: 617
• Identity: 277/617 - (44%)
• Similarity: 379/617 - (61%)
• Gaps: 41/617 - (6%)

  Fly     5 EYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVMPGIT 69
            |:||.|||.||||.||||||::|||.|.:.|||::.|:|..||...|.:..:..|.|:::|||||
 Worm    81 EFRQYGKETVDYIVDYLENIQKRRVVPAIEPGYLKDLIPSEAPNTPESFESVMEDFEKLIMPGIT 145

  Fly    70 HWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLH 134
            |||.|..||||||.||.||::.|||:|||.|:||:||:.||.||||:|:::|.|||||||..||.
 Worm   146 HWQHPRFHAYFPAGNSFPSIIADMLSDAIGCVGFSWAACPAMTELELIMLDWFGKMIGLPAEFLP 210

  Fly   135 LSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSSVEKA 199
            |:...:||||:|::|||...|.|||.|...::...:|.|..::..:.::|:||||.:||||||||
 Worm   211 LTENGKGGGVIQSSASECNFVTLLAARFEVMKELRQRFPFVEEGLLLSKLIAYCSKEAHSSVEKA 275

  Fly   200 ALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGIVCAE 264
            .:||:|::|.:|.|....:||..||.||::|...||:||:|..|||||..||||.|.|||.:|.|
 Worm   276 CMIGMVKLRILETDSKFRLRGDTLRNAIQEDRNLGLIPFFVSTTLGTTSCCSFDVLSEIGPICKE 340

  Fly   265 HHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVHRTFNV 329
            :.|||||||||:||||||||||..:.|||.|.|...||:|||:::||.:.:||||...:.:...|
 Worm   341 NELWLHVDAAYSGSAFICPEFRPLMNGIEYAMSFNTNPNKWLLINFDCSTMWVRDRFKLTQALVV 405

  Fly   330 EPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLAD 394
            :||||||.....::|:.||.||||||||:||:|||:|.|||.|||::|||.||||:|.|.|:.||
 Worm   406 DPLYLQHSWMDKSIDYRHWGIPLSRRFRSLKLWFVIRMYGIDGLQKYIREHVRLAKKMETLLRAD 470

  Fly   395 HRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHTT---- 455
            .:||:..:..:|||.||::||:|:.:.||.|||..|.:|.:|:||..::||||.:.:.:.|
 Worm   471 AKFEIVNEVIMGLVCFRMKGDDELNQTLLTRLNASGRIHMVPASLGDRFVIRFCVCAENATDKDI 535

  Fly   456 --------------LDDIVKDWMEIRQVASTVLEEM----NITISNRVYLKETKEK-----NEAF 497
                          |.|.||..:......:..||||    |||        ||.||     |.|.
 Worm   536 EVAYEIIAQATQHVLHDSVKAVIAEEDEEAVALEEMVADLNIT--------ETPEKCLTRQNSAN 592

  Fly   498 GSSLLLSNSPLSPKVVNGSFAAIFDADEFLAKTYAGVRIAHQESPSMRRRVRGILMSG-KQFSLD 561
            .:.   |...|..::......|....:....|....||:.........:.||.:.|:. ::.|.|
 Worm   593 AAE---SGQKLERQLSKEEILAQKQHESLAKKRSFLVRMVSDPKCYNPKIVRHLNMANHRKMSQD 654

  Fly   562 SHMDVVVQTTLDAGNGATRTSTTNSYGHTTSA 593
            .:.|..:..|:.......|.|  .|.|...||
 Worm   655 LYRDRTLMQTISHSQRPNRLS--QSPGSAGSA 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	203/377 (54%)
tdc-1	NP_495743.1	Pyridoxal_deC	111..489	CDD:278699	203/377 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830