DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdc and DDC

DIOPT Version :9

Sequence 1:	NP_001260855.1	Gene:	Hdc / 36076	FlyBaseID:	FBgn0005619	Length:	847	Species:	Drosophila melanogaster
Sequence 2:	NP_000781.2	Gene:	DDC / 1644	HGNCID:	2719	Length:	480	Species:	Homo sapiens

Alignment Length:	476	Identity:	253/476 - (53%)
Similarity:	345/476 - (72%)	Gaps:	3/476 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVM 65
            |:..|:|:||||||||:|:|:|.|..|:|:|||.|||:|.|:|.:||.|.:.:..|.:|||:|:|
Human     1 MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIM 65

  Fly    66 PGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPD 130
            ||:|||.||:..||||..:|.|::|.|||..||.|:||:||:||||||||.::|:|||||:.||.
Human    66 PGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPK 130

  Fly   131 AFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSS 195
            |||: ....:||||:|.:|||||||.|||.||:.|.|.....|....|.|..:||||.|||||||
Human   131 AFLN-EKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSS 194

  Fly   196 VEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGI 260
            ||:|.|||.|:::.|.:|.:.|||...|:||:|.|...||:||::.||||||..||||||.|:|.
Human   195 VERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGP 259

  Fly   261 VCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVHR 325
            :|.:..:|||||||||||||||||||..|.|:|.|||..|||.|||:|:||.:|:||:..|.:..
Human   260 ICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTG 324

  Fly   326 TFNVEPLYLQ--HENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFE 388
            .|.::|.||:  |::||:..|:.||||||.||||:||:|||.|.||:||||.:||:.|:|:.:||
Human   325 AFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFE 389

  Fly   389 ALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTH 453
            :||..|.|||:..:..||||.||::|.|::.|.||:|:|....:|.:|..|:.::|:||.|.|..
Human   390 SLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRT 454

  Fly   454 TTLDDIVKDWMEIRQVASTVL 474
            .....:.:.|..|:::|:.||
Human   455 VESAHVQRAWEHIKELAADVL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	213/379 (56%)
DDC	NP_000781.2	Pyridoxal_deC	35..414	CDD:365998	213/379 (56%)
DDC	NP_000781.2	2 X approximate tandem repeats	58..178		68/120 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730