Protein Alignment Hdc and Hdc

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: XP_006498847.1
• Gene: Hdc / 15186
• MGIID: 96062
• Length: 681
• Species: Mus musculus
• Alignment Length: 894
• Identity: 165/894 - (18%)
• Similarity: 274/894 - (30%)
• Gaps: 301/894 - (33%)

  Fly     4 KGITLSAILEQGATRRRKSPPKEECPKKQKRDSWRKVNNGFECGMIAAVLNKCESKRTHDEVRLL 68
            :||. :.||.:|.|...| |..:.||            |.....:.|..:|.....|:.|...::
Mouse    58 RGIK-NGILNRGFTASFK-PTSQRCP------------NSASNPVAALPVNFHPESRSSDSSVIV 108

  Fly    69 E--SEPEVVKQILERRKRNVEYKERVLETEDEPEIIEKKALKLAQAIAKANHLIVYTG------A 125
            :  |:|..|                    .:.|.::.....:|...:.:...|..|.|      |
Mouse   109 QPFSKPGYV--------------------TNSPRVLSSNPSELLFDLTQDTGLSHYQGGPTLSIA 153

  Fly   126 GI----------------STSAKIPDYRGSQGIWTLLEQGKDIGEYDLSLADPTYTHMALFELHR 174
            |:                |.:.|.|  :.::.|     .|.|......|...|:.  |:|..:..
Mouse   154 GLNETSFLSKRPSGSDISSVNPKKP--KPNENI-----SGTDASSVVSSEKSPSV--MSLQVVPS 209

  Fly   175 RGILKHVLSQNCDGLHLRSG--LPR--------FSLSEVHGNMYVEVCKQCKPNAEYWRLFDTTQ 229
            :|       .||.....::|  .||        |:|.:...|.....|.....|  :..|..|..
Mouse   210 QG-------TNCSSNQSKNGTTFPRACPKCNIHFNLLDPLKNHMTYCCPDMINN--FLGLTKTDN 265

  Fly   230 FTARHYHKTNRRCRRCGGPLIDTIVHFGERGQLKWPLN------WAGVTPHTEKTDLILCIGSSL 288
            ..:.:..||           :|:     |:|:|...:|      :.|.....:||.......|.|
Mouse   266 LNSANEAKT-----------LDS-----EKGKLIMLVNDFYYGKYEGDVQEEQKTHTTFKCFSCL 314

  Fly   289 KVLR------------------------KYTWLWATDRPIKKRPKIF----IINLQWTPKDKVST 325
            |||:                        |:|   ......::.|..|    .|....||.:..:.
Mouse   315 KVLKNNIRFMNHMKHHLELEKQSSESWEKHT---TCQHCYRQFPTPFQLQCHIESTHTPHEFSTI 376

  Fly   326 LKINGKCDQVMMLVMKHLNIDVPVYNRLKDPIFAHATLLLADEQHTASQPMLKKTTATTKEENTE 390
            .||.....:...::::|:.                      |.......|.:.:..      |..
Mouse   377 CKICELSFETEQILLQHMK----------------------DNHKPGEMPYICQVC------NYR 413

  Fly   391 ESASSERESETKTE----TSLSASTCASAQQM---YLNNLILAQQQKISTNYNILLSPAGRSES- 447
            .|..||.||..:|.    .:|....|....::   |:::.:..|::.|.......|......|.
Mouse   414 SSLFSEVESHFRTSHENTKNLLCPFCLKVIKIATPYMHHYMKHQKKGIHRCTKCRLQFLTCKEKM 478

  Fly   448 -------RGSLGPGHLPPLVP--CLTTSSGADQTKSEPNNNPTTSSESKSAPSSPP-------AN 496
                   |..:.|..|..|.|  .:|..:.....:|..:..|:.|:.:.:...|||       .|
Mouse   479 DHKTQHHRTFVKPKQLEGLPPGTKVTIRASVAPLQSGSSVTPSISASTSTLQLSPPRTENVTAKN 543

  Fly   497 VIKIDTAS-NLFGNLRHVLTTMNSVGCSGLLDSKPRPVDE-----AKSAEKLVISQQEKYKRILT 555
            .:|::|:: |         ||:          |.|...:|     :||..:..:|..:|.:..|:
Mouse   544 HVKLNTSTPN---------TTI----------SDPSKTNEIKSNGSKSKNRSKVSNMQKKQSTLS 589

  Fly   556 YYKTAIQQHQQQTSTANAALPQWYDVNYAYSGLHSIIHPPPPDVNLWGCGSTLK-LEPQQPLEIE 619
               .:.::.:..|:..|..|.:         |:|..|.          |.|.:| .....|..:.
Mouse   590 ---NSNKKSKVNTALRNLRLRR---------GVHECIE----------CSSEVKDFANHFPTYVH 632

  Fly   620 CKFCFEN------YSQHSCQFYPPQPAEFTVKSY---------RRGKPVVCECCDF--------- 660
            |.||..|      |..|...|:..:|:    |.|         .||..:||..|||
Mouse   633 CSFCRYNTSCSKAYVNHMMSFHSNRPS----KRYCIFKKHSENLRGISLVCLNCDFLTDVSGLDN 693

  Fly   661 -----SDGE-----------------SEKYQPDMTEAAASSLASTSKAAAGDGGKTISSTSAVER 703
                 |..|                 ||:.....|||......|.||..|..  .|.........
Mouse   694 MATHLSQHETHTCQVLVEKVSVCIPTSERLSELKTEAPTKGQESVSKETARH--STAEREPGASH 756

  Fly   704 TDLLEQKRRPLADEESKEADARVTKRAKCESESAVGDSASPSNVTKNGT 752
            ::..:.|..|..|:..::|..       ||:.:|..   ...|||.:.|
Mouse   757 SESKQDKAPPSEDDTGRDASV-------CEAAAAAN---RERNVTASDT 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	73/449 (16%)
Hdc	XP_006498847.1	Pyridoxal_deC	62..440	CDD:395219	73/445 (16%)