DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdc and Gad2

DIOPT Version :9

Sequence 1:	NP_001260855.1	Gene:	Hdc / 36076	FlyBaseID:	FBgn0005619	Length:	847	Species:	Drosophila melanogaster
Sequence 2:	NP_032104.2	Gene:	Gad2 / 14417	MGIID:	95634	Length:	585	Species:	Mus musculus

Alignment Length:	505	Identity:	121/505 - (23%)
Similarity:	215/505 - (42%)	Gaps:	116/505 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 YMRQLLPE-SAPIEGEPWPKIFSDVERIVMPGITHWQSPHMHA-------YFPALNS---MPSLL 90
            |..:||.| :..:..:|     .::|.|    :||.|:...:|       ||..|::   |..|.
Mouse   137 YPNELLQEYNWELADQP-----QNLEEI----LTHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLA 192

  Fly    91 GDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPDAFLHLSSQSQGGGVLQTTASEATLV 155
            .|.|....|...||:..:|....||.:.:..:.::||.|.        ..|.|:.....:.:.:.
Mouse   193 ADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPG--------GSGDGIFSPGGAISNMY 249

  Fly   156 CLLAGRTRAIQRFHERHPGYQDAEINA--RLVAYCSDQAHSSVEKAAL---IGLVRMRYIEADDD 215
            .:|..|       ::..|..::..:.|  ||:|:.|:.:|.|::|.|.   ||...:..|:.|:
Mouse   250 AMLIAR-------YKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDE- 306

  Fly   216 LAMRGKLLREAIED---DIKQ-GLVPFWVCATLGTTGSCSFDNLEEIGIVCAEHHLWLHVDAAYA 276
               |||::...:|.   ::|| |.|||.|.||.|||...:||.|..:..:|.::.:|:|||||:.
Mouse   307 ---RGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWG 368

  Fly   277 GSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDS------TAVHRTFNVEPLYLQ 335
            |...:..:.:..|.|:|||:|:.:||.|.:.|....:||.||:.      ..:|.::    |:.|
Mouse   369 GGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQSCNQMHASY----LFQQ 429

  Fly   336 HENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEALVLADHRFELP 400
            .::..::.|.....:...|.....|:|.:.|:.|..|.:.||.:.:.||:....::.....:|:
Mouse   430 DKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYTIIKNREGYEM- 493

  Fly   401 AKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHC---IPSSLKGQYVIRFTITSTHTTLDDIVKD 462
                    ||  .|..:.|..            |   :|.||:              ||:|..:.
Mouse   494 --------VF--DGKPQHTNV------------CFWFVPPSLR--------------TLEDNEER 522

  Fly   463 WMEIRQVASTVLEEMNITISNRVYLKETKEKNEAFGSSLLLSNSPLSPKV 512
            ...:.:||..:                 |.:...:|:: ::|..||..||
Mouse   523 MSRLSKVAPVI-----------------KARMMEYGTT-MVSYQPLGDKV 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	103/401 (26%)
Gad2	NP_032104.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Pyridoxal_deC	138..509	CDD:278699	105/425 (25%)
		Substrate binding. /evidence=ECO:0000250	181..183		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810