DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdc and Gad1

DIOPT Version :9

Sequence 1:	NP_001260855.1	Gene:	Hdc / 36076	FlyBaseID:	FBgn0005619	Length:	847	Species:	Drosophila melanogaster
Sequence 2:	NP_032103.2	Gene:	Gad1 / 14415	MGIID:	95632	Length:	593	Species:	Mus musculus

Alignment Length:	464	Identity:	118/464 - (25%)
Similarity:	199/464 - (42%)	Gaps:	92/464 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EMVDYIADYLENI--RERRVFPDVSPGYMRQLLPESAPIEG---------EPWPKIFSDVERIVM 65
            |:||.:.:|:...  |..:|.....|   .|||   ..:||         |...:|..|....:.
Mouse   118 EVVDILLNYVRKTFDRSTKVLDFHHP---HQLL---EGMEGFNLELSDHPESLEQILVDCRDTLK 176

  Fly    66 PGITHWQSPHMHAYFPALNS---MPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIG 127
            .|:   ::.|.. :|..|::   :..|.|:.|....|...||:..:|....:|.|.:..:.:::|
Mouse   177 YGV---RTGHPR-FFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVG 237

  Fly   128 LPDAFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINA--RLVAYCSD 190
            .        |...|.|:.....:.:.:..::|.|       ::..|..:...:.|  :||.:.|:
Mouse   238 W--------SNKDGDGIFSPGGAISNMYSIMAAR-------YKYFPEVKTKGMAAVPKLVLFTSE 287

  Fly   191 QAHSSVEKA-ALIGLVRMRYIEADDDLAM-----RGKLLREAIED---DIKQ-GLVPFWVCATLG 245
            .:|.|::|| |.:|.       ..|::.:     |||::...:|.   |.|| |.||.:|.||.|
Mouse   288 HSHYSIKKAGAALGF-------GTDNVILIKCNERGKIIPADLEAKILDAKQKGYVPLYVNATAG 345

  Fly   246 TTGSCSFDNLEEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHF 310
            ||...:||.::||..:|.:::||||||||:.|...:..:.|..|.|||||:|:.:||.|.:.|..
Mouse   346 TTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVLL 410

  Fly   311 DATALWVRDSTAVHRTFNVEPLYL-----QHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGI 370
            ..:|:.|::...:.....:...||     |::   |:.|.....|...|.....|.|.:.::.|.
Mouse   411 QCSAILVKEKGILQGCNQMCAGYLFQPDKQYD---VSYDTGDKAIQCGRHVDIFKFWLMWKAKGT 472

  Fly   371 KGLQRHIREGVRLAQKFEALVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHC- 434
            .|.:..|.:.:.||....|.:.....||:         ||  .|:.|.|..            |
Mouse   473 VGFENQINKCLELADYLYAKIKNREEFEM---------VF--DGEPEHTNV------------CF 514

  Fly   435 --IPSSLKG 441
              ||.||:|
Mouse   515 WYIPQSLRG 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	103/406 (25%)
Gad1	NP_032103.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Pyridoxal_deC	143..517	CDD:365998	107/431 (25%)
		Substrate binding. /evidence=ECO:0000250	189..191		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810