Protein Alignment Hdc and Tdc2

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: XP_308519.3
• Gene: Tdc2 / 1269865
• VectorBaseID: AGAMI1_013508
• Length: 642
• Species: Anopheles gambiae
• Alignment Length: 676
• Identity: 296/676 - (43%)
• Similarity: 411/676 - (60%)
• Gaps: 59/676 - (8%)

  Fly     1 MDFKEYRQRGKEMVDYIADYLENIRERRVFPDVSPGYMRQLLPESAPIEGEPWPKIFSDVERIVM 65
            ||.||:|:||.|||:||.:|||.:.:|||.|.|.|||::..||:.||.|.|||.||..|||..:|
Mosquito     1 MDSKEFRRRGTEMVEYICNYLETLEQRRVTPCVEPGYLKHQLPDEAPEEPEPWEKIMQDVEDKIM 65

  Fly    66 PGITHWQSPHMHAYFPALNSMPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGLPD 130
            ||:||||.|..|||||:.||.||:|||||:|.|.|:||:||:||||||||.||::||||.|||||
Mosquito    66 PGVTHWQHPRFHAYFPSGNSFPSILGDMLSDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130

  Fly   131 AFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINARLVAYCSDQAHSS 195
            :||.|...|:||||:||:|||..||.:||.|.:||:...::||..::..:.::|:||||.:|||.
Mosquito   131 SFLALKPGSRGGGVIQTSASECVLVTMLAARAQAIKYLKQQHPFVEEGHLLSKLMAYCSKEAHSC 195

  Fly   196 VEKAALIGLVRMRYIEADDDLAMRGKLLREAIEDDIKQGLVPFWVCATLGTTGSCSFDNLEEIGI 260
            |||||:|..|::|.:|.|:...:|...|.:|:|:|.:|||:||:|..||||||||:||:|.|||.
Mosquito   196 VEKAAMISFVKLRILEPDEKCCLRADTLIKAMEEDEQQGLIPFFVSTTLGTTGSCAFDDLAEIGE 260

  Fly   261 VCAEH-HLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFDATALWVRDSTAVH 324
            ..... .:||||||||||:||||||.:..|:||:.|||...||:|||:.:||.:.|||||...:.
Mosquito   261 ALQRFPSVWLHVDAAYAGNAFICPELKYLLKGIQYADSFNTNPNKWLLTNFDCSTLWVRDRIRLT 325

  Fly   325 RTFNVEPLYLQHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIKGLQRHIREGVRLAQKFEA 389
            ....|:||||||..:..|:|:.||.:|||||||:||:|||||||||.|||.:||..:.||::|||
Mosquito   326 SALVVDPLYLQHGYTDSAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQAYIRHHIELAKRFEA 390

  Fly   390 LVLADHRFELPAKRHLGLVVFRIRGDNEITEKLLKRLNHRGNLHCIPSSLKGQYVIRFTITSTHT 454
            |||.|.|||:..:..||||.||::|.:.|.||||..:|..|.||.:|:|:...|||||...:.:.
Mosquito   391 LVLKDSRFEVCNEVRLGLVCFRLKGTDRINEKLLSSINASGKLHMVPASVNDTYVIRFCAVAQNA 455

  Fly   455 TLDDIVKDWMEIRQVASTVLE-EMNITISNRVYLKET---KEKNEAFGSSLLLSNSPLSPKVVNG 515
            .::||...|..|...||.:|| |....:|..|..::|   .:|...|  ..::|:    ||:.|
Mosquito   456 KVEDIDYAWDVITDFASEILEKEQADEVSEIVDRRKTHTLAQKRSFF--VRMVSD----PKIYN- 513

  Fly   516 SFAAIFDAD-------EFLAKTYAG--VRIAHQESPSMRRRVRGILMSGKQFSLDSHMDVVVQTT 571
              .||..|.       |..:..:.|  |::...::|.....:...|             ..:..:
Mosquito   514 --PAINKAQTPHRMSTELTSPGHDGTVVKVQSPKTPGSATWISWPL-------------AFLFAS 563

  Fly   572 LDAGNGATRTSTTNSYGHTTSAAQANSERQASIQEDNEESPEETELLSLCRTSNVPSPEHAHSLS 636
            .|.|   |:...|..:.|..:..:.::.|:.|....:..|||....::|              |.
Mosquito   564 ADDG---TKNDVTLRFRHLDTMMRLSASRRNSATGGSSPSPEAENGITL--------------LK 611

  Fly   637 TPSRSCSSSSHSLIHSLTQSSPRSSP 662
            :|.:|      .::.....|||...|
Mosquito   612 SPKKS------PILMRKRGSSPNPPP 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	215/378 (57%)
Tdc2	XP_308519.3	Pyridoxal_deC	35..414	CDD:395219	215/378 (57%)