DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hdc and gad1a

DIOPT Version :9

Sequence 1:	NP_001260855.1	Gene:	Hdc / 36076	FlyBaseID:	FBgn0005619	Length:	847	Species:	Drosophila melanogaster
Sequence 2:	XP_002663350.1	Gene:	gad1a / 100329827	ZFINID:	ZDB-GENE-070912-472	Length:	591	Species:	Danio rerio

Alignment Length:	505	Identity:	114/505 - (22%)
Similarity:	213/505 - (42%)	Gaps:	100/505 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EMVDYIADYLENI--RERRVFPDVSP--------GYMRQLLPESAPIEGEPWPKIFSDVERIVMP 66
            |:|:.:.:|:...  |..:|.....|        |:..:|..:...:|     :|..|....:..
Zfish   116 EVVEILTNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELCDQPESLE-----QILVDCRDTLKY 175

  Fly    67 GITHWQSPHMHAYFPALNS---MPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGL 128
            |:   ::.|.. :|..|:|   :..|.|:.|....|...||:..:|....:|.:.:..:.:::|.
Zfish   176 GV---RTGHPR-FFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIVGW 236

  Fly   129 PDAFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINA-----RLVAYC 188
            |:        .:|.|:.....:.:.:..::..          |:..|.:.:|..     |||.:.
Zfish   237 PN--------GEGDGIFSPGGAISNMYSVMVA----------RYKHYPEIKIKGMAAAPRLVLFT 283

  Fly   189 SDQAHSSVEKAALI---GLVRMRYIEADDDLAMRGKLLREAIED---DIKQ-GLVPFWVCATLGT 246
            |:.:|.|::||:.:   |...:..:..|:    ||:::...:|.   |.|| |.||.:|.||.|:
Zfish   284 SEHSHYSIKKASAVLGFGTENLILLRTDE----RGRVIPADLEAKVIDAKQKGFVPMFVNATAGS 344

  Fly   247 TGSCSFDNLEEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFD 311
            |...:||.:.||..:|.::::|||||.|:.|...:..:.:..|.|||||:|:.:||.|.:.|...
Zfish   345 TVYGAFDPINEIADICEKYNMWLHVDGAWGGGLLMSRKHKHKLSGIERANSVTWNPHKMMGVPLQ 409

  Fly   312 ATALWVRDSTAVHRTFNVEPLYL-----QHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIK 371
            .:|:.||:...:....::...||     |::   |..|.....|...|.....|.|.:.:|.|..
Zfish   410 CSAILVREKGLLQGCNSMCAGYLFQPDKQYD---VTYDTGDKAIQCGRHVDIFKFWLMWKSKGTT 471

  Fly   372 GLQRHIREGVRLAQKFEALVLADHRFELPAK---RHLGLVVF------RIRGDNEITEKLLKRLN 427
            |.::||...:.|::.....:.....:|:..:   :|..:..:      |:..|.|  ||     .
Zfish   472 GFEKHIDRCLELSEYLYHKIKNREGYEMVFQGEPQHTNVCFWYIPPSLRLLPDGE--EK-----R 529

  Fly   428 HRGNLHCIPSSLK----------------GQYV--IRFTITSTHTTLDDI 459
            ||  ||.:...:|                |:.|  .|..:::...|..||
Zfish   530 HR--LHKVAPKIKALMMECGTTMVGYQPQGEKVNFFRMVVSNPAVTRSDI 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_001260855.1	Pyridoxal_deC	35..413	CDD:278699	94/414 (23%)
gad1a	XP_002663350.1	Pyridoxal_deC	141..515	CDD:278699	93/407 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910