Protein Alignment Hdc and gad1a

DIOPT Version :10

• Sequence 1: NP_523679.2
• Gene: Hdc / 36076
• FlyBaseID: FBgn0005619
• Length: 847
• Species: Drosophila melanogaster
• Sequence 2: XP_002663350.1
• Gene: gad1a / 100329827
• ZFINID: ZDB-GENE-070912-472
• Length: 591
• Species: Danio rerio
• Alignment Length: 505
• Identity: 114/505 - (22%)
• Similarity: 213/505 - (42%)
• Gaps: 100/505 - (19%)

  Fly    12 EMVDYIADYLENI--RERRVFPDVSP--------GYMRQLLPESAPIEGEPWPKIFSDVERIVMP 66
            |:|:.:.:|:...  |..:|.....|        |:..:|..:...:|     :|..|....:..
Zfish   116 EVVEILTNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELCDQPESLE-----QILVDCRDTLKY 175

  Fly    67 GITHWQSPHMHAYFPALNS---MPSLLGDMLADAINCLGFTWASSPACTELEIIVMNWLGKMIGL 128
            |:   ::.|.. :|..|:|   :..|.|:.|....|...||:..:|....:|.:.:..:.:::|.
Zfish   176 GV---RTGHPR-FFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIVGW 236

  Fly   129 PDAFLHLSSQSQGGGVLQTTASEATLVCLLAGRTRAIQRFHERHPGYQDAEINA-----RLVAYC 188
            |:        .:|.|:.....:.:.:..::..          |:..|.:.:|..     |||.:.
Zfish   237 PN--------GEGDGIFSPGGAISNMYSVMVA----------RYKHYPEIKIKGMAAAPRLVLFT 283

  Fly   189 SDQAHSSVEKAALI---GLVRMRYIEADDDLAMRGKLLREAIED---DIKQ-GLVPFWVCATLGT 246
            |:.:|.|::||:.:   |...:..:..|:    ||:::...:|.   |.|| |.||.:|.||.|:
Zfish   284 SEHSHYSIKKASAVLGFGTENLILLRTDE----RGRVIPADLEAKVIDAKQKGFVPMFVNATAGS 344

  Fly   247 TGSCSFDNLEEIGIVCAEHHLWLHVDAAYAGSAFICPEFRTWLRGIERADSIAFNPSKWLMVHFD 311
            |...:||.:.||..:|.::::|||||.|:.|...:..:.:..|.|||||:|:.:||.|.:.|...
Zfish   345 TVYGAFDPINEIADICEKYNMWLHVDGAWGGGLLMSRKHKHKLSGIERANSVTWNPHKMMGVPLQ 409

  Fly   312 ATALWVRDSTAVHRTFNVEPLYL-----QHENSGVAVDFMHWQIPLSRRFRALKVWFVLRSYGIK 371
            .:|:.||:...:....::...||     |::   |..|.....|...|.....|.|.:.:|.|..
Zfish   410 CSAILVREKGLLQGCNSMCAGYLFQPDKQYD---VTYDTGDKAIQCGRHVDIFKFWLMWKSKGTT 471

  Fly   372 GLQRHIREGVRLAQKFEALVLADHRFELPAK---RHLGLVVF------RIRGDNEITEKLLKRLN 427
            |.::||...:.|::.....:.....:|:..:   :|..:..:      |:..|.|  ||     .
Zfish   472 GFEKHIDRCLELSEYLYHKIKNREGYEMVFQGEPQHTNVCFWYIPPSLRLLPDGE--EK-----R 529

  Fly   428 HRGNLHCIPSSLK----------------GQYV--IRFTITSTHTTLDDI 459
            ||  ||.:...:|                |:.|  .|..:::...|..||
Zfish   530 HR--LHKVAPKIKALMMECGTTMVGYQPQGEKVNFFRMVVSNPAVTRSDI 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hdc	NP_523679.2	Pyridoxal_deC	35..413	CDD:395219	94/414 (23%)
gad1a	XP_002663350.1	Pyridoxal_deC	141..515	CDD:395219	93/407 (23%)