DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lztr1 and rdx

DIOPT Version :9

Sequence 1:XP_006248769.1 Gene:Lztr1 / 360745 RGDID:1309100 Length:862 Species:Rattus norvegicus
Sequence 2:NP_650326.3 Gene:rdx / 41704 FlyBaseID:FBgn0264493 Length:829 Species:Drosophila melanogaster


Alignment Length:467 Identity:110/467 - (23%)
Similarity:176/467 - (37%) Gaps:121/467 - (25%)


- Green bases have known domain annotations that are detailed below.


  Rat   226 CNFPVAVCRDKMFVFSGQSG--AKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQ------RRY 282
            ||.....|..::.|...|:.  |::|:|| .........:|:|       |||.|:      ..:
  Fly   421 CNAAANFCDKRLPVNECQASQTARVTSNL-HASSSTMAVSRVP-------SPPLPEVNTPVAENW 477

  Rat   283 GHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGA--------EVPERAS 339
            .:|.|...:..|::      |:.|...|.:   :..||::.|:.|  .||        .|..:..
  Fly   478 CYTQVKVVKFSYMW------TINNFSFCRE---EMGEVLKSSTFS--AGANDKLKWCLRVNPKGL 531

  Rat   340 SSEEASTLT----------SEERSSFKKS------------------RDVFGLDFGTTSTKQPVH 376
            ..|....|:          ||.|:.||.|                  |.|.|.|:|.....:...
  Fly   532 DEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDF 596

  Rat   377 LASE----LPSGRL--FHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWE 435
            |..|    ||..:|  |...:|::|::.|          ||:....||. .|:|.|.||.|.|::
  Fly   597 LLDEANGLLPEDKLTIFCEVSVVADSVNI----------SGQSNIVQFK-VPECKLSEDLGNLFD 650

  Rat   436 GRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIVQAREWLAQKLEEDGALAPKEAPGSTVGR 500
            ..:|.||...:|.:|  .|.|.||:.|||           :..|...|.:              .
  Fly   651 NEKFSDVTLSVGGRE--FQAHKAILAARS-----------DVFAAMFEHE--------------M 688

  Rat   501 ARPPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 565
            ....|.||||.:.:....:.:::|:||.|.....| ..:|:|...|.|.|.      :|:.:|.:
  Fly   689 EERKLNRVAITDVDHEVLKEMLRFIYTGKAPNLEK-MADDLLAAADKYALE------KLKVMCEE 746

  Rat   566 YIEASVDLQNVLAVCECAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERL---SSPLIVEIVR 627
            .:..::.::........|......|||...::||  .:|...|:....::.:   .|.||.|..|
  Fly   747 ALCVNLSVETAAETLILADLHSADQLKAQTIDFI--NTHATDVMETSGWQNMITTHSHLIAEAFR 809

  Rat   628 --RKQQPPPRTP 637
              ..||.||..|
  Fly   810 ALATQQIPPIGP 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lztr1XP_006248769.1 KELCH repeat 65..111 CDD:276965
Kelch_3 74..123 CDD:290151
KELCH repeat 115..169 CDD:276965
Kelch_3 124..180 CDD:290151
Kelch_1 171..216 CDD:279660
Kelch_3 234..289 CDD:290151 14/62 (23%)
Kelch_1 280..323 CDD:279660 8/42 (19%)
KELCH repeat 281..323 CDD:276965 8/41 (20%)
SPOP_C_like 571..631 CDD:269810 13/64 (20%)
BTB 662..761 CDD:279045
BTB 665..762 CDD:197585
SPOP_C_like 765..>800 CDD:269810
rdxNP_650326.3 MATH_SPOP 483..621 CDD:239743 31/148 (21%)
BTB 645..749 CDD:279045 33/137 (24%)
BTB 656..752 CDD:197585 30/129 (23%)
SPOP_C 752..814 CDD:269807 13/63 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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