Protein Alignment Hr3 and NR1D2

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_005117.3
• Gene: NR1D2 / 9975
• HGNCID: 7963
• Length: 579
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 156/599 - (26%)
• Similarity: 261/599 - (43%)
• Gaps: 160/599 - (26%)

  Fly   383 AATTTATSATSAAAATSAATASATATSARENSREHSSSSSGSNG----AMTAQIE---------- 433
            |..::::||:|.|:..|..:.::..:|:.......:||:|.:||    ...|.||
Human    10 AYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDLANIEGILKNDRIDC 74

  Fly   434 -------------------------IIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNY-Q 472
                                     ::.||||||.:||.||||..|||||||||||....:.| :
Human    75 SMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKK 139

  Fly   473 CPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKV----------------- 520
            |.:|:.|.:.|:||||||.||.:|||.:|||||||:|||:.|::::::
Human   140 CLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFS 204

  Fly   521 ----EDEVRFHRAQ--MRAQSDAAP----DSSVYDTQTPSSSD-----------QLHHNN--YNS 562
                .|.:..|..|  :.||....|    :.....:.:|.|||           :.|.:.  ||.
Human   205 GHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQ 269

  Fly   563 GGYSNNEVGYGSPYGYSASVTPQQ-------TMQYDISADYVDS--TTYEPRSTIIDPEFISHAD 618
            ....|:          :.|:.||:       ..||:::.|:..:  :::.|.|     |...|.:
Human   270 EQQENS----------AESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCS-----ESQQHLN 319

  Fly   619 GDINDVLIKTLAEAHA---------------------------------------NTNTKLEAVH 644
            |......|......||                                       ||..::..|.
Human   320 GQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVC 384

  Fly   645 DMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSF 709
            .| .|.|.|.     .:....|:|.:.:...|..::.::||||.||||..|||.||:.|||.|:|
Human   385 PM-SKSPYVD-----PHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTF 443

  Fly   710 ELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEM---RLVSRIFQTAKSIAELKLTETELA 771
            |:.:||.:.|.|..:..|.:    |..:.:...|...|   .|::.:|:.::.:..|:|::.|::
Human   444 EVLMVRFASLFDAKERTVTF----LSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMS 504

  Fly   772 LYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISI 836
            |:.::||:..:|:|:.....::.|....:.|:|..:..||   ..:.::...||..:|:.|.::.
Human   505 LFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH---PNEASIFTKLLLKLPDLRSLNN 566

  Fly   837 LHMESLSKFKLQHP 850
            :|.|.|..||: ||
Human   567 MHSEELLAFKV-HP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	54/150 (36%)
		NR_LBD	620..862	CDD:472173	66/273 (24%)
NR1D2	NP_005117.3	Modulating	1..99		15/88 (17%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q60674	1..60		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..61		11/47 (23%)
		NR_DBD_REV_ERB	98..186	CDD:143540	50/87 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	222..250		7/27 (26%)
		NR_LBD_REV_ERB	389..577	CDD:132738	55/199 (28%)
		Interaction with ZNHIT1. /evidence=ECO:0000269|PubMed:17892483	397..579		54/189 (29%)