Protein Alignment Hr3 and NR1D1

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_068370.1
• Gene: NR1D1 / 9572
• HGNCID: 7962
• Length: 614
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 160/614 - (26%)
• Similarity: 280/614 - (45%)
• Gaps: 118/614 - (19%)

  Fly   326 PALARSSSFSSLSSFSSISNISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTTATS 390
            |:.....|..|.:|..|..:::..|..... .|..|||.:...|:...:||..:...:.:::::|
Human    24 PSRTSPESLYSDNSNGSFQSLTQGCPTYFP-PSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSS 87

  Fly   391 ATSAAAATSAATASATATSARENSREHSSSSSGS----NGAMTAQIEIIPCKVCGDKSSGVHYGV 451
            ::|:::..:.:...:...:..::||...|.|:.:    ||.      ::.||||||.:||.||||
Human    88 SSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGM------VLLCKVCGDVASGFHYGV 146

  Fly   452 ITCEGCKGFFRRSQSSVVNY-QCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKK 515
            ..|||||||||||....:.| :|.:|:.|.:.|:||||||.||.:|||.:|||||||:|||:.|:
Human   147 HACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKR 211

  Fly   516 QREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSP-YGYS 579
            :::::       .|:|::..:.|  ::...:|.|..:....|......|.|.......|| .|:|
Human   212 EKQRM-------LAEMQSAMNLA--NNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFS 267

  Fly   580 ---------ASVTPQQTMQ---YDISADYVDSTTYEPRSTIIDP-EF-ISHADG----------- 619
                     .|.:|:.|::   ..::..:.:..||........| .| .:||.|
Human   268 QFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWE 332

  Fly   620 --------DINDVLIKTLAEAHANTNTKLE--------------AVHDMFRKQPDVSRI----LY 658
                    :.|:.|   .|:.|......|.              |.|...:...:..|:    :|
Human   333 NQGCPPAPNDNNTL---AAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVY 394

  Fly   659 YKNLGQ--------------------------------EELWLDCAEKLTQMIQNIIEFAKLIPG 691
            ....|:                                :|:|.|.:...|..::.::||||.|||
Human   395 AAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPG 459

  Fly   692 FMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEM---RLVSRI 753
            |..|||.||:.|||.|:||:.:||.:.|.::....|::    |.:..:...:...|   .|:|.:
Human   460 FRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMF----LSRTTYSLQELGAMGMGDLLSAM 520

  Fly   754 FQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDV 818
            |..::.:..|.|||.||.|:.::||:..:|:|:..:..:::|....:.|:| .|...:.||  :.
Human   521 FDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALR-ALVLKNRPL--ET 582

  Fly   819 TVLDTLLNNIPNFRDISILHMESLSKFKL 847
            :....||..:|:.|.::.:|.|.|..|::
Human   583 SRFTKLLLKLPDLRTLNNMHSEKLLSFRV 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	50/94 (53%)
		NR_LBD	620..862	CDD:472173	67/281 (24%)
NR1D1	NP_068370.1	Modulating	1..128		20/104 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..119		18/95 (19%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q3UV55	1..70		11/46 (24%)
		Crucial for activation of GJA1. /evidence=ECO:0000250	49..284		79/250 (32%)
		NR_DBD_REV_ERB	127..215	CDD:143540	51/93 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	233..285		11/51 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..345		6/33 (18%)
		NR_LBD	418..611	CDD:472173	57/199 (29%)