Protein Alignment Hr3 and NR1I2

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_071285.1
• Gene: NR1I2 / 8856
• HGNCID: 7968
• Length: 473
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 129/533 - (24%)
• Similarity: 211/533 - (39%)
• Gaps: 99/533 - (18%)

  Fly   359 QEGSLKRTKERTPPPMPPLTTHKPAATTTATSATSAAAATSAATASATATSARENSREHS----- 418
            :||||:         .|.:..|         ||.:..|:.......|......:.|..|:
Human    10 KEGSLR---------APAIPLH---------SAAAELASNHPRGPEANLEVRPKESWNHADFVHC 56

  Fly   419 --SSSSGSNGAMTAQIEI---IPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCP-RNK 477
              :.|.....::.|..|:   ..|:|||||::|.|:.|:|||||||||||:.......:|| |..
Human    57 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKG 121

  Fly   478 QCVVDRVNRNRCQYCRLQKCLKLG------MSRDAVKFGR--MSKKQREK-------VEDEVRFH 527
            .|.:.|..|.:||.|||:|||:.|      ||.:||:..|  :.:|:.|:       |:......
Human   122 ACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQ 186

  Fly   528 RAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDI 592
            |..:|...||  ....:||...      |..|:...|..::  |...|....|....:......:
Human   187 RMMIRELMDA--QMKTFDTTFS------HFKNFRLPGVLSS--GCELPESLQAPSREEAAKWSQV 241

  Fly   593 SADYVD-STTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRI 656
            ..|... ..:.:.|.          .||.:.:.      :..|::..|     ::|...|.:
Human   242 RKDLCSLKVSLQLRG----------EDGSVWNY------KPPADSGGK-----EIFSLLPHM--- 282

  Fly   657 LYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLD 721
                           |:..|.|.:.||.|||:|..|..|..:|||.|||..:|||..:|.:.:.:
Human   283 ---------------ADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFN 332

  Fly   722 LSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGV 786
            ........|.:....|.  |:...:..|:..:.:....:.:|:|.|.|..|.|::.|..|:|.||
Human   333 AETGTWECGRLSYCLED--TAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGV 395

  Fly   787 RGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPN 851
            ..:..:.:|.......::..:|.|. |......:...::..:...|.|:..|.:.|.:.:..||.
Human   396 LQHRVVDQLQEQFAITLKSYIECNR-PQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 459

  Fly   852 VVFPALYKELFSI 864
            ..  .|.:|||.|
Human   460 AT--PLMQELFGI 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	45/112 (40%)
		NR_LBD	620..862	CDD:472173	52/241 (22%)
NR1I2	NP_071285.1	NR_DBD_PXR	79..166	CDD:143536	40/86 (47%)
		NR_LBD_PXR_like	182..467	CDD:132732	67/338 (20%)