Protein Alignment Hr3 and Nr1i2

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_443212.1
• Gene: Nr1i2 / 84385
• RGDID: 69057
• Length: 431
• Species: Rattus norvegicus
• Alignment Length: 466
• Identity: 122/466 - (26%)
• Similarity: 196/466 - (42%)
• Gaps: 115/466 - (24%)

  Fly   437 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCP-RNKQCVVDRVNRNRCQYCRLQKCLKL 500
            |:|||||::|.|:.|:|||||||||||:....|..:|| |...|.:.|..|.:||.|||:|||:.
  Rat    38 CRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLES 102

  Fly   501 GMSRD------AVKFGR--MSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHH 557
            ||.::      ||:..|  :.:|:|||:|                ||
  Rat   103 GMKKEMIMSDAAVEQRRALIKRKKREKIE----------------AP------------------ 133

  Fly   558 NNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDS--TTYEPRSTIIDPEFISHADGD 620
                             |.|.......||.:..::....:.:  ||:........|. :.|:|.:
  Rat   134 -----------------PPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPA-VFHSDCE 180

  Fly   621 INDVLIKTLAEAHANTNTKLEAVHD----------------MFRKQPDVSRILYYKNLGQEELWL 669
            :.:||..:|.|..|   |..:.:.|                ::..||.      .|:.|:|.:.|
  Rat   181 LPEVLQASLLEDPA---TWSQIMKDSVPMKISVQLRGEDGSIWNYQPP------SKSDGKEIIPL 236

  Fly   670 --DCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQN------- 725
              ..|:..|.|.:.:|.|||:|..|..|..:|||.|||..:||:.|:|.:.:.|....
  Rat   237 LPHLADVSTYMFKGVINFAKVISHFRELPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRL 301

  Fly   726 AVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNT 790
            |..:.|   |...|      :..|:..:.:....:.:|:|.|.|..|.|::.|..|:|.||...:
  Rat   302 AYCFED---PNGGF------QKLLLDPLMKFHCMLKKLQLREEEYVLMQAISLFSPDRPGVVQRS 357

  Fly   791 ---EIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNV 852
               ::|..|.|::.|.   :|.:. |......:...::..:...|.|:....:.|.:.:..||..
  Rat   358 VVDQLQERFALTLKAY---IECSR-PYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDTHPFA 418

  Fly   853 VFPALYKELFS 863
            .  .|.:||||
  Rat   419 T--PLMQELFS 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	45/95 (47%)
		NR_LBD	620..862	CDD:472173	63/269 (23%)
Nr1i2	NP_443212.1	NR_DBD_like	37..124	CDD:413390	40/85 (47%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		8/25 (32%)
		Hinge	105..142		12/87 (14%)
		NR_LBD	140..425	CDD:472173	69/309 (22%)