Protein Alignment Hr3 and VDR

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001351014.1
• Gene: VDR / 7421
• HGNCID: 12679
• Length: 494
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 105/437 - (24%)
• Similarity: 185/437 - (42%)
• Gaps: 98/437 - (22%)

  Fly   437 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLG 501
            |.||||:::|.|:..:||||||||||||......:.||.|..|.:.:.||..||.|||::|:.:|
Human    24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIG 88

  Fly   502 MSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQ----------LH 556
            |.::.:......:::||.:         ..|.:.:|..||     ..|..|::          .|
Human    89 MMKEFILTDEEVQRKREMI---------LKRKEEEALKDS-----LRPKLSEEQQRIIAILLDAH 139

  Fly   557 HNNY----------------NSGGYSN----NEVGYGSPYGYSASVTPQQTMQYDISADYVDSTT 601
            |..|                |.||.|:    |.....|..|.|:|......:   .|:|.:||::
Human   140 HKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCI---TSSDMMDSSS 201

  Fly   602 YEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEE 666
            :    :.:|   :|..|.|...|.::                                  |.|..
Human   202 F----SNLD---LSEEDSDDPSVTLE----------------------------------LSQLS 225

  Fly   667 LWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGD 731
            :....|:.::..||.:|.|||:||||..|:.:|||:|||:.:.|:.::|.:....:...:...|:
Human   226 MLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGN 290

  Fly   732 VMLPQEAFY-----TSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTE 791
                |:..|     |.....:.|:..:.:....:.:|.|.|.|..|..::.::.|:|.||:....
Human   291 ----QDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAAL 351

  Fly   792 IQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILH 838
            |:.:.:...|.::..:...|.| .|...:...::..:.:.|.::..|
Human   352 IEAIQDRLSNTLQTYIRCRHPP-PGSHLLYAKMIQKLADLRSLNEEH 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	35/86 (41%)
		NR_LBD	620..862	CDD:472173	45/224 (20%)
VDR	NP_001351014.1	NR_DBD_VDR	16..122	CDD:143513	39/111 (35%)
		Hinge. /evidence=ECO:0000269|PubMed:10678179	97..126		7/42 (17%)
		NR_LBD_VDR	124..426	CDD:132731	65/323 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..190		9/31 (29%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250|UniProtKB:P13053	246..264		10/17 (59%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	416..424