Protein Alignment Hr3 and NR1H2

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_009052.4
• Gene: NR1H2 / 7376
• HGNCID: 7965
• Length: 460
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 124/516 - (24%)
• Similarity: 212/516 - (41%)
• Gaps: 106/516 - (20%)

  Fly   367 KERTPPPMPPLTTHKPAATTTATSATSAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQ 431
            ||..|.|.|    ..|......|...|:|.:|............|:..:..:....|.
Human    31 KEEGPEPWP----GGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGH------- 84

  Fly   432 IEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRS--QSSVVNYQCPRNKQCVVDRVNRNRCQYCRL 494
             |:  |:|||||:||.||.|::|||||||||||  :.....|.|.....|.:|...|.:||.|||
Human    85 -EL--CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146

  Fly   495 QKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNN 559
            :||.:.||....|    :|::|..|.:...:...:|.::||...|..|......|.:|
Human   147 RKCKEAGMREQCV----LSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGAS------- 200

  Fly   560 YNSGGYSNNEVG-YGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDIND 623
              .||   :|.| .||..|....:|..|                                    :
Human   201 --PGG---SEAGSQGSGEGEGVQLTAAQ------------------------------------E 224

  Fly   624 VLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEK----LTQM----IQ 680
            ::|:.|..|....|.:      .|..||.|:.    ..||.:....|..::    .|::    :|
Human   225 LMIQQLVAAQLQCNKR------SFSDQPKVTP----WPLGADPQSRDARQQRFAHFTELAIISVQ 279

  Fly   681 NIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLY-GDVMLPQEAFYTSDS 744
            .|::|||.:|||::|.::|||.|||..:.|:.::..:|..:.....:.: .|....::.|:.: .
Human   280 EIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRA-G 343

  Fly   745 EEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFN------LSMNAI 803
            .::..::.||:.::::..|.|.:.|.||..::.:...:|..|:....::.|..      ||...|
Human   344 LQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRI 408

  Fly   804 RQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSI 864
            ::..:....|         .:|..:.:.|.:|.:|.|.:...:||...:  |.|..|::.:
Human   409 KRPQDQLRFP---------RMLMKLVSLRTLSSVHSEQVFALRLQDKKL--PPLLSEIWDV 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	41/95 (43%)
		NR_LBD	620..862	CDD:472173	55/256 (21%)
NR1H2	NP_009052.4	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000269|PubMed:25661920	1..85		12/65 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78		11/50 (22%)
		NR_DBD_LXR	67..169	CDD:143534	43/115 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..216		14/58 (24%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000269|PubMed:25661920	219..460		57/298 (19%)
		NR_LBD_LXR	223..458	CDD:132752	56/292 (19%)