Protein Alignment Hr3 and RORC

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: XP_006711547.3
• Gene: RORC / 6097
• HGNCID: 10260
• Length: 572
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 181/516 - (35%)
• Similarity: 259/516 - (50%)
• Gaps: 104/516 - (20%)

  Fly   429 TAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCR 493
            |:|||:||||:|||||||:||||||||||||||||||.....|.|.|.:.|.:||.:|||||:||
Human    77 TSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCR 141

  Fly   494 LQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAP------------DSSVY-- 544
            |||||.||||||||||||||||||:.:..||: .:.|.|.|....|            |:..|
Human   142 LQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQ-KQLQQRQQQQQEPVVKTPPAGAQGADTLTYTL 205

  Fly   545 ---DTQTP--------------------SSSDQLHHNNYNSGG---------YS---NNEVGYGS 574
               |.|.|                    |.|...:.||....|         ||   ....|..|
Human   206 GLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRES 270

  Fly   575 PYGYSASVTPQQT-MQYD----------------ISADYVDSTTYEPRSTIIDPEFISHADGDIN 622
            .|...:.:||.:. ::::                ..:....||...|.:::.:   |.|
Human   271 FYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTE---IEH------ 326

  Fly   623 DVLIKTLAEAHANT-NTKLEAVHDMFRKQPDV---SRILYYKNLGQEELWLDCAEKLTQMIQNII 683
              |::::.:::..| ..:||   |:.|::.::   ..:..|:.....|:|..||..||:.||.::
Human   327 --LVQSVCKSYRETCQLRLE---DLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVV 386

  Fly   684 EFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMR 748
            ||||.:.|||.|.|:|||:|||.|:.|:.:|||.|..:.....|.:.......|.|......|
Human   387 EFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSE-- 449

  Fly   749 LVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRL-FNLSMNAIRQELETNHA 812
            |:|.||..:.|::.|..:|.|:|||.:|||:...|.|::...::::| :||       ||..:|.
Human   450 LISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNL-------ELAFHHH 507

  Fly   813 PLKGDVTVLDTLLNNIP---NFRDISILHMESLSKFKLQHPNVV---FPALYKELFSIDSQ 867
            ..|   |...::|..:|   ..|.:...|:|.|..|:..||.||   ||.|||||||.:::
Human   508 LCK---THRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETE 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	68/93 (73%)
		NR_LBD	620..862	CDD:472173	81/252 (32%)
RORC	XP_006711547.3	NR_DBD_ROR	78..172	CDD:143526	68/93 (73%)
		NR_LBD_ROR_like	322..560	CDD:132737	83/263 (32%)