Protein Alignment Hr3 and RORA

DIOPT Version :9

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_599022.1
• Gene: RORA / 6095
• HGNCID: 10258
• Length: 556
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 187/536 - (34%)
• Similarity: 272/536 - (50%)
• Gaps: 88/536 - (16%)

  Fly   398 TSAATASATATSARENSRE----------HSS-SSSG---------------------------- 423
            |..|..|||.|.|.|.:|.          |.. .|||
Human    28 TGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEV 92

  Fly   424 SNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNR 488
            ..|.|.|||||||||:|||||||:||||||||||||||||||.|...|.|||.|.|::||.:|||
Human    93 QTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNR 157

  Fly   489 CQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQ------SDAAPDSSVYDTQ 547
            ||:|||||||.:|||||||||||||||||:.:..||:.||.|.:.:      .:|.|.:..|:.
Human   158 CQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNI- 221

  Fly   548 TPSSSDQLHH--NNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQ-YDIS-------ADYVDSTTY 602
            :.:...:||.  :||..|..........:...:...:.|..... .||:       .||..::.:
Human   222 SANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGF 286

  Fly   603 EPRSTIIDPEFISHADGDIN--------DVLIKTLAEAHANT----NTKLEAVHDMFRKQPDVSR 655
            .|        :.|..:|:.:        :.|.:.::::|..|    ..:|:.:......|.::..
Human   287 FP--------YCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIEN 343

  Fly   656 ILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLL 720
               |:|..:|.:|..||.|:|:.||.::||||.|.|||.|.|:|||:|||.||.|:..:||.|..
Human   344 ---YQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAF 405

  Fly   721 DLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNG 785
            |...|.|.:.......:.|.:...|:  .:|.:|:..||:..:.|||.|:||:.:.||:..:|:.
Human   406 DSQNNTVYFDGKYASPDVFKSLGCED--FISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSW 468

  Fly   786 VRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHP 850
            ::...:|::|......|::..|:.||.    :..:|..|:..:...|.:...|.|.|..||..:|
Human   469 LQEKVKIEKLQQKIQLALQHVLQKNHR----EDGILTKLICKVSTLRALCGRHTEKLMAFKAIYP 529

  Fly   851 NVV---FPALYKELFS 863
            ::|   ||.||||||:
Human   530 DIVRLHFPPLYKELFT 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
RORA	NP_599022.1	NR_DBD_ROR	99..193	CDD:143526	72/93 (77%)
		NR_LBD_ROR_like	305..544	CDD:132737	77/247 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5145
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2658
Isobase	1	0.950	-	0	Normalized mean entropy	S5442
OMA	1	1.010	-	-		QHG47287
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	1	1.000	-	-		otm40497
orthoMCL	1	0.900	-	-		OOG6_104672
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.920