Protein Alignment Hr3 and RARB

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001277145.1
• Gene: RARB / 5915
• HGNCID: 9865
• Length: 455
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 129/517 - (24%)
• Similarity: 205/517 - (39%)
• Gaps: 148/517 - (28%)

  Fly   372 PPMPPLTTH-KPAATTTATSATSAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEII 435
            ||:..|..| .|:..:|.:.||....:||:.....:..|.....|.:.
Human    39 PPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYK----------------- 86

  Fly   436 PCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKL 500
            ||.||.|||||.||||..|||||||||||....:.|.|.|:|.||:::|.||||||||||||.::
Human    87 PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEV 151

  Fly   501 GMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGY 565
            |||:::|:..| :||::|..:.|.
Human   152 GMSKESVRNDR-NKKKKETSKQEC----------------------------------------- 174

  Fly   566 SNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLA 630
                                 |..|:::|:.                          |.|.:.:.
Human   175 ---------------------TESYEMTAEL--------------------------DDLTEKIR 192

  Fly   631 EAHANT----------NTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEF 685
            :||..|          .|...|.|   |.:.|:.            ||...:|..|:.|..|:||
Human   193 KAHQETFPSLCQLGKYTTNSSADH---RVRLDLG------------LWDKFSELATKCIIKIVEF 242

  Fly   686 AKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMR-- 748
            ||.:|||..|:..|||.|||....::.|:|:.......|:.:.:.|.:       |.:..:|.
Human   243 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGL-------TLNRTQMHNA 300

  Fly   749 ----LVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELET 809
                |...:|..|..:..|::.:||..|..::.|:..:|..:...|::.:|....:.|::..:.
Human   301 GFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIR- 364

  Fly   810 NHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT 871
            ...|.|..  :...:|..|.:.|.||....|.:...|::.|..:.|.:.:.|.:.:..:.||
Human   365 KRRPSKPH--MFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLT 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	51/93 (55%)
		NR_LBD	620..862	CDD:472173	59/257 (23%)
RARB	NP_001277145.1	Modulating	1..87		12/64 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..78		7/30 (23%)
		NR_DBD_RAR	82..166	CDD:143522	50/101 (50%)
		Hinge	154..182		9/90 (10%)
		NR_LBD_RAR	186..416	CDD:132735	59/254 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..455		2/10 (20%)