Protein Alignment Hr3 and Nr1h2

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001385538.1
• Gene: Nr1h2 / 58851
• RGDID: 61906
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 117/505 - (23%)
• Similarity: 214/505 - (42%)
• Gaps: 123/505 - (24%)

  Fly   402 TASATATSARENSREHSSSSSGSNGAMTAQIEII----------------P-------CKVCGDK 443
            :.|:|:.:.:|..:| :....||.|:.:|.|.:|                |       |:|||||
  Rat    21 STSSTSPTIKEEGQE-TDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDK 84

  Fly   444 SSGVHYGVITCEGCKGFFRRS--QSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDA 506
            :||.||.|::|||||||||||  ......|.|..:..|.:|...|.:||.|||:||.:.||....
  Rat    85 ASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQC 149

  Fly   507 VKFGRMSKKQ--REKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNE 569
            |    :|::|  ::|::.:   .:.|....::.|..||.....:|.:|:               .
  Rat   150 V----LSEEQIRKKKIQKQ---QQQQPPPPTEPASGSSARPAASPGTSE---------------A 192

  Fly   570 VGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHA 634
            ...||..|....:|..|                                    :::|:.|..|..
  Rat   193 SSQGSGEGEGIQLTAAQ------------------------------------ELMIQQLVAAQL 221

  Fly   635 NTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEK----LTQM----IQNIIEFAKLIPG 691
            ..|.:      .|..||.|:.    ..||.:....|..::    .|::    :|.|::|||.:||
  Rat   222 QCNKR------SFSDQPKVTP----WPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPG 276

  Fly   692 FMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLY-GDVMLPQEAFYTSDSEEMRLVSRIFQ 755
            |::|.::|||.|||..:.|:.::..:|..:.....:.: .|....::.|:.: ..::..::.||:
  Rat   277 FLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRA-GLQVEFINPIFE 340

  Fly   756 TAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFN------LSMNAIRQELETNHAPL 814
            .::::..|.|.:.|.||..::.:...:|..|:..:.::.|..      ||...|::..:....|
  Rat   341 FSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFP- 404

  Fly   815 KGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSI 864
                    .:|..:.:.|.:|.:|.|.:...:||...:  |.|..|::.:
  Rat   405 --------RMLMKLVSLRTLSSVHSEQVFALRLQDKKL--PPLLSEIWDV 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	44/120 (37%)
		NR_LBD	620..862	CDD:472173	55/256 (21%)
Nr1h2	NP_001385538.1	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250|UniProtKB:P55055	1..76		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69		10/48 (21%)
		NR_DBD_like	58..154	CDD:413390	39/99 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..201		9/58 (16%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:P55055	205..446		57/298 (19%)
		NR_LBD_LXR	209..444	CDD:132752	56/292 (19%)