DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr3 and rorb

DIOPT Version :9

Sequence 1:	NP_001334718.1	Gene:	Hr3 / 36073	FlyBaseID:	FBgn0000448	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001076325.1	Gene:	rorb / 567943	ZFINID:	ZDB-GENE-061204-2	Length:	466	Species:	Danio rerio

Alignment Length:	475	Identity:	184/475 - (38%)
Similarity:	265/475 - (55%)	Gaps:	51/475 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 MTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYC 492
            |.||||:||||:|||||||:||||||||||||||||||.:..:|.|||.:.|::||.||||||:|
Zfish     1 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHC 65

  Fly   493 RLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQ-----SDAAPDSSVYDTQTPSSS 552
            ||||||.||||||||||||||||||:.:..||:.|:.:::.|     .:|...:.||.:...:..
Zfish    66 RLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQTGEAEALARVYSSSLTNGL 130

  Fly   553 DQLHHNNYNSGGYSNNEV-------GYGSPYGY----SASVTPQQTMQYDISADYVDSTTYEPRS 606
            ..|:|.  ..|.|:|..|       ..|:|.||    |...:|.|: ..||:.  :.....||
Zfish   131 STLNHE--IGGTYANGHVIDMPKGQANGAPGGYYGMDSTQASPDQS-GLDITG--MKQIKQEP-- 188

  Fly   607 TIID----PEFISHAD------------GDINDVLIKTLAEAHANT-NTKLEAVHDMFRKQPDVS 654
             |.|    |...::..            |:: |.:.:.:.::|..| ....|.:..:..:.....
Zfish   189 -IYDLTPVPNLFTYGSYQDSQLAPGVSMGEL-DRIAQNIIKSHLETCQYTAEELQQLAWQTHSYE 251

  Fly   655 RILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRL 719
            .:..|::..::.||..||.::|..||.::||||.|.|||.|.|:|||||||:|..|:.:|||.|.
Zfish   252 EVKMYQSKTRDVLWQQCAIQVTHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRA 316

  Fly   720 LDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERN 784
            .:...|.||:.......:.|.|...::  |||.:|..|||:..|:|||.|:||:.:.||:..:|.
Zfish   317 FNPLNNTVLFEGKYGGMQIFKTLGCDD--LVSAVFDFAKSLCSLQLTEEEIALFSAAVLISTDRP 379

  Fly   785 GVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQH 849
            .:....::|:|......|::..::.||.    |...|..|::.||....:..||.|.|..|:..|
Zfish   380 WLMEPRKVQKLQEKIYFALQHIMQKNHL----DEDALAKLISRIPTLSALCTLHTEELQAFQQLH 440

  Fly   850 P---NVVFPALYKELFSIDS 866
            |   |::||.||||||:.|:
Zfish   441 PETVNMLFPPLYKELFNPDA 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
rorb	NP_001076325.1	NR_DBD_ROR	3..97	CDD:143526	71/93 (76%)
rorb	NP_001076325.1	NR_LBD_ROR_like	217..456	CDD:132737	81/245 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5101
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38250
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2662
OMA	1	1.010	-	-		QHG47287
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	1	1.000	-	-		otm24275
orthoMCL	1	0.900	-	-		OOG6_104672
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970