DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr3 and rorca

DIOPT Version :9

Sequence 1:	NP_001334718.1	Gene:	Hr3 / 36073	FlyBaseID:	FBgn0000448	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001076288.1	Gene:	rorca / 559245	ZFINID:	ZDB-GENE-990415-250	Length:	479	Species:	Danio rerio

Alignment Length:	492	Identity:	177/492 - (35%)
Similarity:	258/492 - (52%)	Gaps:	82/492 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 MTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYC 492
            |.||||:||||:|||||||:||||||||||||||||||.:...|.|.|.:.|::||.||||||:|
Zfish     1 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNAMYSCSRQRNCIIDRTNRNRCQHC 65

  Fly   493 RLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFH-RAQMRAQSDAAPDSSVYDTQTPSSSDQLH 556
            ||||||.||||||||||||||||||:.:..||:.| ::|.||.......||       .:.|:..
Zfish    66 RLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQSQERAGGLGNGISS-------HTGDEAG 123

  Fly   557 HN-NYNSGGYSNNEVGYGS-------------PYG--YSASVTPQQTMQYDISADYVDSTTYEPR 605
            .| |.:|..||.     ||             |.|  :...:||::...| .|.:.:..::....
Zfish   124 ENGNGHSRAYSR-----GSSTTLSDLDDITTLPDGLLFDLPLTPEEAADY-CSLELLGGSSGNSS 182

  Fly   606 STIIDPEFISHADGDINDV-------------------------------LIKTLAEAHANTNTK 639
            |:...||......||:..:                               :.:.:.::|..|:.
Zfish   183 SSQSSPESNRQEFGDVTHIKHEYMSPHESGLFTRSILNPPEGCSLMEIERITQNVIKSHIETSQ- 246

  Fly   640 LEAVHDMFR-----KQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDD 699
             .:..::.|     ..|:..|:  |:|...|.||..||.:||..||.::||||.|.|||.|||:|
Zfish   247 -YSTEELKRLAWTLYTPEEIRV--YQNKPTEMLWQQCAVQLTNAIQYVVEFAKRISGFMDLSQND 308

  Fly   700 QILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELK 764
            ||:|||.|..::.::||.|..:...|.:|:.......:.|.....::  |||.:|:.||:::.|:
Zfish   309 QIILLKAGCLDVLLIRMCRAYNPINNTLLFDGKFASPQLFKALGCDD--LVSAVFEMAKTLSRLQ 371

  Fly   765 LTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDV--TVLDTLLNN 827
            |:..|:||:.:.|||.|:|..:....::|:|......|::..|.      |..|  ..|..:::.
Zfish   372 LSGEEMALFTATVLLSPDRPWLTDAQKVQKLQEKVYVALQHYLH------KSGVHEEKLARMVSK 430

  Fly   828 IPNFRDISILHMESLSKFKLQHPNVV--FPALYKELF 862
            :|..:.|..||::.|..|:|.||...  |||||:|:|
Zfish   431 LPMMKSICNLHIDKLEFFRLLHPETAYNFPALYREVF 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
rorca	NP_001076288.1	NR_DBD_ROR	3..97	CDD:143526	70/93 (75%)
rorca	NP_001076288.1	NR_LBD	229..467	CDD:299703	78/249 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5101
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2662
OMA	1	1.010	-	-		QHG47287
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104672
Panther	1	1.100	-	-	LDO	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970