Protein Alignment Hr3 and pparab

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001096037.1
• Gene: pparab / 557714
• ZFINID: ZDB-GENE-990415-211
• Length: 459
• Species: Danio rerio
• Alignment Length: 558
• Identity: 138/558 - (24%)
• Similarity: 222/558 - (39%)
• Gaps: 155/558 - (27%)

  Fly   328 LARSSSFSSLSSFSSISNISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTTATSAT 392
            :::|....:||||           .|..|.|..||                        .:.|:|
Zfish    34 ISQSMDEDALSSF-----------EMTENQSGLGS------------------------GSESST 63

  Fly   393 SAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEI------IPCKVCGDKSSGVHYGV 451
            ...|.|.|                 ||.|||..|....|.|.      :.|:||.|::||.||||
Zfish    64 ELDALTPA-----------------SSPSSGVYGCPVGQDEFTSTSLNLECRVCSDRASGYHYGV 111

  Fly   452 ITCEGCKGFFRRSQSSVVNY-QCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKK 515
            ..||||||||||:....:.| :|.|  :|.:.:.|||:|||||.||||.:|||.:|::||||.:.
Zfish   112 HACEGCKGFFRRTIRLKLEYDKCER--RCKIQKKNRNKCQYCRFQKCLSVGMSHNAIRFGRMPQS 174

  Fly   516 QREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSA 580
            ::.:::.|:      :..:.|...|
Zfish   175 EKLRLKAEI------LTGERDVEDD---------------------------------------- 193

  Fly   581 SVTPQQTMQYDISADYVDSTTYEPRS--TII-----DPEFISHADGDINDVLIKTLAEAHANTNT 638
                |:|:...|...||.:.......  ||:     .|.|:.|.        ::||..|......
Zfish   194 ----QKTLAKQIYEAYVKNFNMNKSKARTILTGKTSTPPFVIHD--------METLQLAEQTFVA 246

  Fly   639 K-LEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQIL 702
            | :.:...:..|.|:| ||.:.           |.....:.:..:.||||.:|||..|..:||:.
Zfish   247 KMMGSCGGLLNKDPEV-RIFHC-----------CQCTSVETVTELTEFAKSVPGFSNLDLNDQVT 299

  Fly   703 LLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYT-----SDSEEMRLVSRIFQTAKSIAE 762
            |||.|..|.....::..::.....|.||...:.:|...:     ||..|.:     ||.|.....
Zfish   300 LLKYGVHEALFAMLASCMNKDGLLVAYGSGFITREFLKSLRRPFSDMMEPK-----FQFAMKFNS 359

  Fly   763 LKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNN 827
            |:|.:::|||:.:.::...:|.|:.....|:|:....:|.:...|::|| |..|  .:...||..
Zfish   360 LELDDSDLALFVAAIICCGDRPGLVNVPHIERMQESIVNVLHLHLKSNH-PDHG--FLFPKLLQK 421

  Fly   828 IPNFRDISILHMESLSKFKLQHPNVVFPAL---YKELF 862
            :.:.|.:...|.:.:.:.|......:.|.|   |::::
Zfish   422 LVDLRQLVTEHAQLIQEIKKTEDTSLHPLLQEIYRDMY 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	46/100 (46%)
		NR_LBD	620..862	CDD:472173	58/250 (23%)
pparab	NP_001096037.1	NR_DBD_Ppar	96..179	CDD:143523	44/84 (52%)
		C4 zinc finger; ZnF_C4	97..161		36/65 (55%)
		NR_LBD_PPAR	193..458	CDD:132730	69/336 (21%)
		ligand binding domain of hormone receptors (HOLI)	279..429		43/157 (27%)