Protein Alignment Hr3 and PPARG

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_056953.2
• Gene: PPARG / 5468
• HGNCID: 9236
• Length: 505
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 152/608 - (25%)
• Similarity: 240/608 - (39%)
• Gaps: 174/608 - (28%)

  Fly   322 LSDPPALARSSSFSSLSSFSSIS-----------------NISSVCKNMASNTSQEGSLKRTKER 369
            |.|.|....|.||:...| ::||                 .||||..::..:.|....:|
Human     5 LGDSPIDPESDSFTDTLS-ANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIK----- 63

  Fly   370 TPPPMPPLTT---------HKPAATTTATSATSA-----------AAATSAATASATATSAREN- 413
                  |.||         |......|.|....|           .:|.....||....|.:..
Human    64 ------PFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQL 122

  Fly   414 -SREHSSSSSGSNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRS-QSSVVNYQCPRN 476
             ::.|...   ||..|.     |.|:|||||:||.||||..||||||||||: :..::..:|..|
Human   123 YNKPHEEP---SNSLMA-----IECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN 179

  Fly   477 KQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDS 541
              |.:.:.:||:|||||.||||.:|||.:|::||||.:.::||:..|:                |
Human   180 --CRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI----------------S 226

  Fly   542 SVYDTQTPSSSD--QLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEP 604
            |..|...|.|:|  .|..:.|:|             |..|..:|..:.     .|.....||.:.
Human   227 SDIDQLNPESADLRALAKHLYDS-------------YIKSFPLTKAKA-----RAILTGKTTDKS 273

  Fly   605 RSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWL 669
            ...|.|...:...:..|....|..|.|     .:|..|:                      .::.
Human   274 PFVIYDMNSLMMGEDKIKFKHITPLQE-----QSKEVAI----------------------RIFQ 311

  Fly   670 DCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVL------ 728
            .|..:..:.:|.|.|:||.||||:.|..:||:.|||.|..|:....::.|  ::::.||
Human   312 GCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL--MNKDGVLISEGQG 374

  Fly   729 -------------YGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLW 780
                         :||.|.|:                 |:.|.....|:|.:::||::.::::|.
Human   375 FMTREFLKSLRKPFGDFMEPK-----------------FEFAVKFNALELDDSDLAIFIAVIILS 422

  Fly   781 PERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKF 845
            .:|.|:.....|:.:.:..:.|:..:|:.||..   ...:...||..:.:.|.|...|::.|...
Human   423 GDRPGLLNVKPIEDIQDNLLQALELQLKLNHPE---SSQLFAKLLQKMTDLRQIVTEHVQLLQVI 484

  Fly   846 KLQ------HPNVVFPALYKELF 862
            |..      ||  :...:||:|:
Human   485 KKTETDMSLHP--LLQEIYKDLY 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	47/94 (50%)
		NR_LBD	620..862	CDD:472173	56/266 (21%)
PPARG	NP_056953.2	PPARgamma_N	31..108	CDD:463633	14/87 (16%)
		NR_DBD_Ppar	138..221	CDD:143523	45/84 (54%)
		Interaction with FAM120B. /evidence=ECO:0000250	205..280		24/108 (22%)
		NR_LBD_PPAR	237..504	CDD:132730	68/335 (20%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	495..503		2/9 (22%)