Protein Alignment Hr3 and PPARD

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_006229.1
• Gene: PPARD / 5467
• HGNCID: 9235
• Length: 441
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 130/576 - (22%)
• Similarity: 229/576 - (39%)
• Gaps: 152/576 - (26%)

  Fly   302 RPAQSRPQQQQQQQQQQVKFLSDPPAL-------ARSSSFSSLSSFSSISNISSVCKNMASNTSQ 359
            :|.:..|:.::::::::|......|.|       ..|||::.||..||
Human     3 QPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSS----------------- 50

  Fly   360 EGSLKRTKERTPPPMPPLTTHKPAATTTATSATSAAAATSAATASATATSARENSREHSSSSSGS 424
                       ||.:                                          ......|.
Human    51 -----------PPSL------------------------------------------LDQLQMGC 62

  Fly   425 NGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQ-CPRNKQCVVDRVNRNR 488
            :||....:. :.|:|||||:||.||||..||||||||||:....:.|: |.|:  |.:.:.|||:
Human    63 DGASCGSLN-MECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERS--CKIQKKNRNK 124

  Fly   489 CQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSD 553
            |||||.||||.||||.:|::||||.:.::.|:            .....|.:.|.|:   |..:|
Human   125 CQYCRFQKCLALGMSHNAIRFGRMPEAEKRKL------------VAGLTANEGSQYN---PQVAD 174

  Fly   554 QLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISH-A 617
            ....:.:....|..|                            .:.|..:.||.:...  .|| |
Human   175 LKAFSKHIYNAYLKN----------------------------FNMTKKKARSILTGK--ASHTA 209

  Fly   618 DGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNI 682
            ...|:|  |:||.:|......| :.|:.: ....::|..::|:          |.....:.::.:
Human   210 PFVIHD--IETLWQAEKGLVWK-QLVNGL-PPYKEISVHVFYR----------CQCTTVETVREL 260

  Fly   683 IEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEM 747
            .||||.||.|..|..:||:.|||.|..|.....::.:::.....|..|...:.:|...:......
Human   261 TEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFS 325

  Fly   748 RLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHA 812
            .::...|:.|.....|:|.:::|||:.:.::|..:|.|:.....::.:.:..:.|:...|:.||.
Human   326 DIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHP 390

  Fly   813 PLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQ------HPNVVFPALYKELF 862
            ..:   .:...||..:.:.|.:...|.:.:.:.|..      ||  :...:||:::
Human   391 DAQ---YLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHP--LLQEIYKDMY 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	48/94 (51%)
		NR_LBD	620..862	CDD:472173	52/247 (21%)
PPARD	NP_006229.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		14/78 (18%)
		NR_DBD_Ppar	73..156	CDD:143523	47/84 (56%)
		NR_LBD_PPAR	173..440	CDD:132730	61/315 (19%)