Protein Alignment Hr3 and nr1d2a

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001124064.2
• Gene: nr1d2a / 402815
• ZFINID: ZDB-GENE-040504-1
• Length: 504
• Species: Danio rerio
• Alignment Length: 536
• Identity: 147/536 - (27%)
• Similarity: 259/536 - (48%)
• Gaps: 75/536 - (13%)

  Fly   346 ISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTTATSATSAAAATSAATASATATSA 410
            |:.||.:.::::.:......:..::|...|||.|....||..:.||                 ..
Zfish    10 IAYVCSSSSASSPESCMSDSSASQSPSSSPPLPTKASRATDLSISA-----------------GM 57

  Fly   411 RENSREHSSSSSGSNGAMTAQIE--IIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNY-Q 472
            .:::|.|:|..|.:|.:...::.  ::.||||||.:||.||||..|||||||||||....:.| :
Zfish    58 LKHTRGHTSDKSLANKSSITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKK 122

  Fly   473 CPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVR------FHRAQM 531
            |.:.:.|.:.|:||||||.||.:|||.:|||||||:|||:.|::::::..|::      .:.:|:
Zfish   123 CLKTESCTIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLLEMQTAMNNMMNNSQL 187

  Fly   532 R-----AQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYD 591
            :     :.||::..||.....:|.||.:.......:...|::.......:.|||||:|
Zfish   188 QHMLHVSPSDSSSSSSASPPDSPRSSTESLVPMDTASSCSSDSGEEDGRFSYSASVSP------- 245

  Fly   592 ISADYVDSTTYEPRSTIIDPEFISHADGDIND--------VLIKTLAEAHANTNTKLEAVHDM-- 646
            .:::.:.....||:..........:..|...:        :..:.::....|.|......|.:
Zfish   246 AASETLSREEEEPQMQCWRRSDCQNTTGPYREQTAQQCIRLPTENMSYCRRNMNEGGNRAHLVCP 310

  Fly   647 FRKQP--DVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSF 709
            ....|  |.||       ...|:|.:.:......::.::||||.||||..|||.||:.|||.|:|
Zfish   311 MSASPFVDASR-------PGHEVWEEFSRSFIPAVREVVEFAKRIPGFQELSQHDQVNLLKAGTF 368

  Fly   710 ELAIVRMSRLLDLSQNAVLY-------GDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTE 767
            |:.:||...|.|:.|..|.:       .|::....|        ..|::.:|:.::.:|.|:|.:
Zfish   369 EVLMVRFVPLFDVQQRTVSFMSGRRYSVDLLRSMGA--------GELLNCMFEFSEKLAALQLND 425

  Fly   768 TELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFR 832
            .|::|:.::||:..:|:.:.....::.|....:.|:|..:..||:   .:.:|...||..:|..|
Zfish   426 EEMSLFSAVVLVSADRSAIEDVVGVEALQESLIRALRNLIMKNHS---NESSVFTKLLLKLPELR 487

  Fly   833 DISILHMESLSKFKLQ 848
            .::.:|.|.|..||:|
Zfish   488 SLNNMHSEELLAFKIQ 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	49/96 (51%)
		NR_LBD	620..862	CDD:472173	62/248 (25%)
nr1d2a	NP_001124064.2	NR_DBD_REV_ERB	81..169	CDD:143540	49/87 (56%)
		NR_LBD	314..502	CDD:472173	57/205 (28%)