Protein Alignment Hr3 and Nr1h5

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: XP_006501686.1
• Gene: Nr1h5 / 381463
• MGIID: 3026618
• Length: 593
• Species: Mus musculus
• Alignment Length: 471
• Identity: 112/471 - (23%)
• Similarity: 186/471 - (39%)
• Gaps: 130/471 - (27%)

  Fly   437 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLG 501
            |.|||||:||.||..:||||||||||||.:....|.|.....|.:|...|.:||.|||:||..:|
Mouse   210 CMVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYSCKNGGHCEMDMYMRRKCQECRLKKCKAVG 274

  Fly   502 MSRDAV--KFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSG- 563
            |..:.:  :....||:.|:..:.....:.| ::.:.:.|      ||:..|||.:       ||
Mouse   275 MLAECLLTEIQCKSKRLRKNFKHGPALYPA-IQVEDEGA------DTKHVSSSTR-------SGK 325

  Fly   564 GYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKT 628
            |..:|                            :..|..|.|                   |:.|
Mouse   326 GVQDN----------------------------MTLTQEEHR-------------------LLNT 343

  Fly   629 LAEAHANTNTKLEAVHDMFRK--QPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPG 691
            :...|..:...|.....:.::  .|::|             :|..:|.....||.:::|.|.:||
Mouse   344 IVTVHQKSMIPLGETSKLLQEGSNPELS-------------FLRLSEVSVLHIQGLMKFTKGLPG 395

  Fly   692 FMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLP---------------QEAFYT 741
            |..|:.:||..|.|....|:..:.:::|.....:.  .|..|.|               .|:.::
Mouse   396 FENLTTEDQAALQKASKTEVMFLHVAQLYGGKDST--SGSTMRPAKPSAGTLEVHNPSADESVHS 458

  Fly   742 SD--------SEEMRLVSRIFQTAKS-----IAELKLTETELALYQSLVLLWPERNGVRGNTEI- 792
            .:        |..:..:::.|..:.|     ::||.:::||.||..:..:|:.:|..::....|
Mouse   459 PENFLKEGYPSAPLTDITKEFIASLSYFYRRMSELHVSDTEYALLTATTVLFSDRPCLKNKQHIE 523

  Fly   793 -------QRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHP 850
                   |.||..| .....|...:.|.|.|.:|.|.||.::          |.|.|..:|.:.|
Mouse   524 NLQEPVLQLLFKFS-KMYHPEDPQHFAHLIGRLTELRTLSHS----------HSEILRMWKTKDP 577

  Fly   851 NVVFPALYKELFSIDS 866
            .:|.  |:.|.:.:.|
Mouse   578 RLVM--LFSEKWDLHS 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	39/88 (44%)
		NR_LBD	620..862	CDD:472173	58/279 (21%)
Nr1h5	XP_006501686.1	NR_DBD_FXR	207..290	CDD:143520	37/79 (47%)
		NR_LBD_Fxr	335..585	CDD:132734	59/296 (20%)