DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr3 and Rorc

DIOPT Version :9

Sequence 1:	NP_001334718.1	Gene:	Hr3 / 36073	FlyBaseID:	FBgn0000448	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_006232988.2	Gene:	Rorc / 368158	RGDID:	1595785	Length:	508	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	194/525 - (36%)
Similarity:	268/525 - (51%)	Gaps:	84/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 RENSREHSSSSS--GSNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQC 473
            |...|.|.:|..  .:....|:|||:||||:|||||||:||||||||||||||||||...|.|.|
  Rat     3 RAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSC 67

  Fly   474 PRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEV--RFHRAQMRAQSD 536
            .|.:.|.:||.:|||||:|||||||.||||||||||||||||||:.:..||  :..:.|.|.|..
  Rat    68 TRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQREQVA 132

  Fly   537 AAP-------DSSVY-----DTQTP-SSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQ-- 586
            ..|       |:..|     |.|.| .:|..|...:....|..... |.|.||..:.:.|..|
  Rat   133 KTPPAGSHGADTLTYTLGVPDGQLPLGASPDLPEASACPPGLLRAS-GSGPPYSNTLAKTEVQGA 196

  Fly   587 --TMQYD------ISADYVDST------------TYEPR---STIIDPEFISHAD---GDINDV- 624
              .::|.      ...|.:.||            ..||.   .:...|.|.|..:   ..:.|:
  Rat   197 SCHLEYSPERGKAEGRDSIYSTDGQLTLGRRGLQLGEPEQGSDSHCSPSFCSAPEAPYASLTDIE 261

  Fly   625 -LIKTLAEAHANT-NTKLEAVHDMFRKQPDV---SRILYYKNLGQEELWLDCAEKLTQMIQNIIE 684
             |::.:.:::..| ..:||   |:.|::.::   ..:..|:.....|:|..||..||:.||.::|
  Rat   262 YLVQNVCKSYRETCQLRLE---DLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVE 323

  Fly   685 FAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVL----YGDVMLPQEAFYTSDSE 745
            |||.:.|||.|.|:|||:|||.|:.|:.:|||.|..:.:.:.|.    ||.|    |.|......
  Rat   324 FAKRLSGFMELCQNDQIILLKAGAMEVVLVRMCRAYNANNHTVFFEGKYGGV----ELFRALGCS 384

  Fly   746 EMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRL-FNLSMNAIRQELET 809
            |  |:|.||..:..::.|..:|.|:|||.:|||:...|.|::....::.| :||       ||..
  Rat   385 E--LISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNL-------ELAF 440

  Fly   810 NHAPLKGDVTVLDTLLNNIP---NFRDISILHMESLSKFKLQHPNVV---FPALYKELFS--IDS 866
            :|...|   |....||..:|   ..|.:...|:|.|..|:..||.||   ||.|||||||  |:|
  Rat   441 HHHLCK---THRQGLLAKLPPKGKLRSLCSQHVEKLQDFQHLHPIVVQAAFPPLYKELFSTDIES 502

  Fly   867 QQDLT 871
            .:.|:
  Rat   503 SEGLS 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
Rorc	XP_006232988.2	NR_DBD_ROR	24..118	CDD:143526	69/93 (74%)
Rorc	XP_006232988.2	NR_LBD_ROR_like	258..496	CDD:132737	85/256 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5015
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2581
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	1	1.000	-	-		otm44639
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.060