DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr3 and Rorb

DIOPT Version :9

Sequence 1:	NP_001334718.1	Gene:	Hr3 / 36073	FlyBaseID:	FBgn0000448	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_001257887.1	Gene:	Rorb / 309288	RGDID:	1306778	Length:	459	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	188/475 - (39%)
Similarity:	266/475 - (56%)	Gaps:	59/475 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 MTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYC 492
            |.||||:||||:|||||||:||||||||||||||||||.:..:|.|||.:.|::||.||||||:|
  Rat     1 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHC 65

  Fly   493 RLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQ-----SDAAPDSSVYDTQTPSSS 552
            ||||||.||||||||||||||||||:.:..||:.|:.:::.|     .:|...:.||.:   |.|
  Rat    66 RLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSS---SIS 127

  Fly   553 DQLHHNNYNSGG-YSNNEV-------GY-----GSPYGYSASVTPQQTMQYDISADYVDSTTYEP 604
            :.|.:.|..:|| |:|..|       ||     |.|       :|.|:   .:....:.....||
  Rat   128 NGLSNLNTETGGTYANGHVIDLPKSEGYYNIDSGQP-------SPDQS---GLDMTGIKQIKQEP 182

  Fly   605 RSTIID----PEFISHA---DGDIN--------DVLIKTLAEAHANT-NTKLEAVHDMFRKQPDV 653
               |.|    |...:::   :|.:.        |.:.:.:.::|..| ...:|.:|.:..:....
  Rat   183 ---IYDLTSVPNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTY 244

  Fly   654 SRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSR 718
            ..|..|::..:|.||..||.::|..||.::||||.|.|||.|.|:|||||||:|..|:.:|||.|
  Rat   245 EEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCR 309

  Fly   719 LLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPER 783
            ..:...|.||:.......:.|....|::  ||:..|..||::..|:|||.|:||:.|.||:.|:|
  Rat   310 AFNPLNNTVLFEGKYGGMQMFKALGSDD--LVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDR 372

  Fly   784 NGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQ 848
            ..:....::|:|......|::..::.||.    |...|..|:..||....:..||.|.|..||..
  Rat   373 AWLLEPRKVQKLQEKIYFALQHVIQKNHL----DDETLAKLIAKIPTITAVCNLHGEKLQVFKQS 433

  Fly   849 HPNVV---FPALYKELFSID 865
            ||::|   ||.||||||:.|
  Rat   434 HPDIVNTLFPPLYKELFNPD 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
Rorb	NP_001257887.1	NR_DBD_ROR	3..97	CDD:143526	71/93 (76%)
Rorb	NP_001257887.1	NR_LBD_ROR_like	210..450	CDD:132737	85/245 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5015
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38250
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2581
OMA	1	1.010	-	-		QHG47287
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	1	1.000	-	-		otm44639
orthoMCL	1	0.900	-	-		OOG6_104672
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.970