Protein Alignment Hr3 and Rorb

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001257887.1
• Gene: Rorb / 309288
• RGDID: 1306778
• Length: 459
• Species: Rattus norvegicus
• Alignment Length: 475
• Identity: 188/475 - (39%)
• Similarity: 266/475 - (56%)
• Gaps: 59/475 - (12%)

  Fly   428 MTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYC 492
            |.||||:||||:|||||||:||||||||||||||||||.:..:|.|||.:.|::||.||||||:|
  Rat     1 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHC 65

  Fly   493 RLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQ-----SDAAPDSSVYDTQTPSSS 552
            ||||||.||||||||||||||||||:.:..||:.|:.:::.|     .:|...:.||.:   |.|
  Rat    66 RLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSS---SIS 127

  Fly   553 DQLHHNNYNSGG-YSNNEV-------GY-----GSPYGYSASVTPQQTMQYDISADYVDSTTYEP 604
            :.|.:.|..:|| |:|..|       ||     |.|       :|.|:   .:....:.....||
  Rat   128 NGLSNLNTETGGTYANGHVIDLPKSEGYYNIDSGQP-------SPDQS---GLDMTGIKQIKQEP 182

  Fly   605 RSTIID----PEFISHA---DGDIN--------DVLIKTLAEAHANT-NTKLEAVHDMFRKQPDV 653
               |.|    |...:::   :|.:.        |.:.:.:.::|..| ...:|.:|.:..:....
  Rat   183 ---IYDLTSVPNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTY 244

  Fly   654 SRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSR 718
            ..|..|::..:|.||..||.::|..||.::||||.|.|||.|.|:|||||||:|..|:.:|||.|
  Rat   245 EEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCR 309

  Fly   719 LLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPER 783
            ..:...|.||:.......:.|....|::  ||:..|..||::..|:|||.|:||:.|.||:.|:|
  Rat   310 AFNPLNNTVLFEGKYGGMQMFKALGSDD--LVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDR 372

  Fly   784 NGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQ 848
            ..:....::|:|......|::..::.||.    |...|..|:..||....:..||.|.|..||..
  Rat   373 AWLLEPRKVQKLQEKIYFALQHVIQKNHL----DDETLAKLIAKIPTITAVCNLHGEKLQVFKQS 433

  Fly   849 HPNVV---FPALYKELFSID 865
            ||::|   ||.||||||:.|
  Rat   434 HPDIVNTLFPPLYKELFNPD 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	71/93 (76%)
		NR_LBD	620..862	CDD:472173	85/253 (34%)
Rorb	NP_001257887.1	NR_DBD_ROR	3..97	CDD:143526	71/93 (76%)
		NR_LBD_ROR_like	210..450	CDD:132737	85/245 (35%)