Protein Alignment Hr3 and thraa

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_571471.1
• Gene: thraa / 30670
• ZFINID: ZDB-GENE-990415-263
• Length: 427
• Species: Danio rerio
• Alignment Length: 488
• Identity: 121/488 - (24%)
• Similarity: 217/488 - (44%)
• Gaps: 120/488 - (24%)

  Fly   411 RENSREHSSSSSGSN----GAMTAQIE-IIPCKVCGDKSSGVHYGVITCEGCKGFFRRS-QSSV- 468
            |:||:...:|:|..:    |.:.:.:| ..||.|||||::|.||..||||||||||||: |.::
Zfish    26 RKNSQCSMNSTSDKSISVPGYVPSYLEKDEPCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLH 90

  Fly   469 VNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRA 533
            .:|.|..:..|::|::.||:||.||.:||:.:||:.|.|            ::|..|..:.::
Zfish    91 PSYSCKYDSCCIIDKITRNQCQLCRFRKCISVGMAMDLV------------LDDSKRVAKRRL-- 141

  Fly   534 QSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVD 598
                     :.:.:.....:::....:|
Zfish   142 ---------IEENREKRKKEEIVKTLHN------------------------------------- 160

  Fly   599 STTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLG 663
                .|..|:.:.|            ||:.:.|||.:||.  :..|   .||   .|....:::|
Zfish   161 ----RPEPTVSEWE------------LIRMVTEAHRHTNA--QGPH---WKQ---KRKFLPEDIG 201

  Fly   664 QE------------ELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRM 716
            |.            |.:.:..:.:|..|..:::|||.:|.|..|..:|||:|||....|:..:|.
Zfish   202 QSPAPTSDNDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRA 266

  Fly   717 SRLLD-LSQNAVLYGDVMLPQEAFYTSDSEEMRLVS-RIFQTAKSIAELKLTETELALYQSLVLL 779
            :...| .|:...|.|::.:.:|......   :.:|| .||...||:::..|.::|:||.|:::|:
Zfish   267 AVRYDPESETLTLSGEMAVSREQLKNGG---LGVVSDAIFDLGKSLSQFNLDDSEVALLQAVLLM 328

  Fly   780 WPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVT-VLDTLLNNIPNFRDISILHMESLS 843
            ..:|:|:....:|::...:.:.|....:  ||.  |.::: ....||..:.|.|.|...|.....
Zfish   329 SSDRSGLTCVEKIEKCQEMYLLAFEHYI--NHR--KHNISHFWPKLLMKVTNLRMIGACHASRFL 389

  Fly   844 KFKLQHPNVVFPALYKELF-------SIDSQQD 869
            ..|::.|..:||.|:.|:|       .:.:|:|
Zfish   390 HMKVECPTELFPPLFLEVFEDQEGSTGVAAQED 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	41/96 (43%)
		NR_LBD	620..862	CDD:472173	66/256 (26%)
thraa	NP_571471.1	Modulating	1..56		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		5/13 (38%)
		NR_DBD_TR	56..142	CDD:143519	41/108 (38%)
		NR_LBD_TR	168..407	CDD:132733	66/265 (25%)