Protein Alignment Hr3 and nr1d2b

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_571140.1
• Gene: nr1d2b / 30271
• ZFINID: ZDB-GENE-990415-244
• Length: 578
• Species: Danio rerio
• Alignment Length: 644
• Identity: 163/644 - (25%)
• Similarity: 258/644 - (40%)
• Gaps: 208/644 - (32%)

  Fly   337 LSSFSSISNISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTTATSATSAAAATSAA 401
            :||.||.|:..| |.:.:||:|.:..           .||.|......|            ...|
Zfish    13 ISSSSSASSPES-CHSDSSNSSFQSC-----------SPPHTGQGQGET------------LHVA 53

  Fly   402 TASATATSARENSREHSSSSSG---SNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRR 463
            :.|.........:|..||:.||   .||.      ::.||||||.:||.||||..||||||||||
Zfish    54 SHSRPPRHGGGKARSLSSTKSGITKINGL------VLLCKVCGDVASGFHYGVHACEGCKGFFRR 112

  Fly   464 SQSSVVNY-QCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKV------- 520
            |....:.| :|.:|:.|.:.|:||||||.||.:|||.:|||||||:|||:.|::::::
Zfish   113 SIQQNIQYKKCLKNESCPIMRINRNRCQQCRFKKCLLVGMSRDAVRFGRIPKREKQRMLLEMQNA 177

  Fly   521 ------------------------------EDEV-----RFHRAQMRA-QSDAAPDSSV---YDT 546
                                          ||..     |...:..|: :|:::||..:   .||
Zfish   178 MNNMMNNSHGNQSLNNQTSAADGTSEDGTSEDSTSGPSSRSPSSSPRSNRSESSPDPELQIAMDT 242

  Fly   547 QTPSSSDQL-------------------------------------------------HHNNYNS 562
            .:.|.|...                                                 |.||.:|
Zfish   243 SSSSDSSSATDSGEEEVIGTVTRAHQETFMYNQEQGSMASEALNNYSHCTEKTQEVLNHQNNVSS 307

  Fly   563 GGYSNNEVGYGSPYG-------YSA-SVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADG 619
            ....|.:...| |.|       ||. |..|.:..........:.:.|:...:   |.|  :||:|
Zfish   308 VSEQNPQSSCG-PQGPEDSGQDYSTLSSCPVRLSNNSSRGPSLQTLTFRAHN---DHE--THANG 366

  Fly   620 DINDVLIKTLAEAH-------ANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQ 677
               ..::.|...|:       .||:..::         |..|         ...:|.:.:...|.
Zfish   367 ---SYIVPTFPRANRMHLVCPMNTSPYVD---------PQKS---------GHSIWEEFSMSFTP 410

  Fly   678 MIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLY------------- 729
            .::.::||||.||||..|||.||:.|||.|:||:.:||.:.|.|:.:..|.:
Zfish   411 AVREVVEFAKRIPGFKDLSQHDQVSLLKAGTFEVLVVRFTSLFDVKERKVTFLSGRKYSVDALRS 475

  Fly   730 ---GDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTE 791
               ||                 |::.:|...:.:..|.|:|.|::|:.::||:..:|:|:.....
Zfish   476 LGAGD-----------------LLNSMFDFTEKLQALNLSEEEMSLFTAVVLVSADRSGLENVNS 523

  Fly   792 IQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHP 850
            ::.|....:.|:|..:..||   ..::.:...||..:|:.|.::.:|.|.|..||: ||
Zfish   524 VEALQETLIRALRSLITKNH---PNEIAIFTKLLLKLPDLRSLNNMHSEQLLAFKV-HP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	52/131 (40%)
		NR_LBD	620..862	CDD:472173	61/254 (24%)
nr1d2b	NP_571140.1	NR_DBD_REV_ERB	81..169	CDD:143540	51/93 (55%)
		NR_LBD_REV_ERB	388..576	CDD:132738	54/225 (24%)