DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr3 and Rora

DIOPT Version :9

Sequence 1:	NP_001334718.1	Gene:	Hr3 / 36073	FlyBaseID:	FBgn0000448	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_038938751.1	Gene:	Rora / 300807	RGDID:	1308419	Length:	523	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	189/522 - (36%)
Similarity:	280/522 - (53%)	Gaps:	59/522 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 PAATTTATSATSAAAAT--SAATASATATSARENSREHSSSSSGSNG------AMTAQIEIIPCK 438
            |||:...:|.:.|||.:  :..|..|...|....:....|.:|.|.|      ..|:||||||||
  Rat    10 PAASEPGSSGSEAAAGSRETPLTQDAGRKSEAPGAGRRQSYASSSRGISVTKKTHTSQIEIIPCK 74

  Fly   439 VCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMS 503
            :|||||||:||||||||||||||||||.|...|.|||.|.|::||.:|||||:|||||||.:|||
  Rat    75 ICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMS 139

  Fly   504 RDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPS---SSDQLHHNNYNSGGY 565
            ||||||||||||||:.:..||:.||.|.: |.|........:..||:   |::.|...:.:...|
  Rat   140 RDAVKFGRMSKKQRDSLYAEVQKHRMQQQ-QRDHQQQPGEAEPLTPTYNISANGLTELHDDLSTY 203

  Fly   566 SNNEVGYGSPYGYSAS-------VTPQQTMQYDIS-------ADYVDSTTYEPRSTIIDPEFISH 616
            .:.....||....:.|       .:|.|: ..||:       .||..::.:.|        :.|.
  Rat   204 MDGHTPEGSKADSAVSSFYLDIQPSPDQS-GLDINGIKPEPICDYTPASGFFP--------YCSF 259

  Fly   617 ADGDIN--------DVLIKTLAEAHANT----NTKLEAVHDMFRKQPDVSRILYYKNLGQEELWL 669
            .:|:.:        :.|.:.::::|..|    ..:|:.:......|.::..   |:|..:|.:|.
  Rat   260 TNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIEN---YQNKQREVMWQ 321

  Fly   670 DCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVML 734
            .||.|:|:.||.::||||.|.|||.|.|:|||:|||.||.|:..:||.|..|...|.|.:.....
  Rat   322 LCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYA 386

  Fly   735 PQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLS 799
            ..:.|.:...|:  .:|.:|:..||:..:.|||.|:||:.:.||:..:|:.::...:|::|....
  Rat   387 SPDVFKSLGCED--FISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKI 449

  Fly   800 MNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVV---FPALYKEL 861
            ..|::..|:.||.    :..:|..|:..:...|.:...|.|.|..||..:|::|   ||.|||||
  Rat   450 QLALQHVLQKNHR----EDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKEL 510

  Fly   862 FS 863
            |:
  Rat   511 FT 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
Rora	XP_038938751.1	NR_DBD_ROR	66..160	CDD:143526	71/93 (76%)
Rora	XP_038938751.1	NR_LBD_ROR_like	272..511	CDD:132737	77/247 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5015
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2581
OMA	1	1.010	-	-		QHG47287
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	1	1.000	-	-		otm44639
orthoMCL	1	0.900	-	-		OOG6_104672
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970