Protein Alignment Hr3 and vdra

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_570994.1
• Gene: vdra / 30076
• ZFINID: ZDB-GENE-000210-31
• Length: 453
• Species: Danio rerio
• Alignment Length: 505
• Identity: 117/505 - (23%)
• Similarity: 213/505 - (42%)
• Gaps: 103/505 - (20%)

  Fly   402 TASATATSARENSREHSSSSSGSNGAMTAQIEIIP------------------CKVCGDKSSGVH 448
            |.::...|..::..|..:..|..||..|:.::::.                  |.|||||::|.|
Zfish     3 TENSAVNSGGKSKCEAGACESTVNGDATSLMDLMAVSTSATGQDQFDRNAPPICGVCGDKATGFH 67

  Fly   449 YGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMS 513
            :..:||||||||||||.....::.||.|..|.:.:.||..||.|||::|:.:||.::.:    ::
Zfish    68 FNAMTCEGCKGFFRRSMKRKASFTCPFNGNCTITKDNRRHCQACRLKRCIDIGMMKEFI----LT 128

  Fly   514 KKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGY 578
            .::.::.:|.:...:.:..|:....|..|....|..:|..:.||..|:.
Zfish   129 DEEVQRKKDLIMKRKEEEAAREARKPRLSDEQMQIINSLVEAHHKTYDD---------------- 177

  Fly   579 SASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAV 643
                            .|.|...:.|               .:.:..:...|...|:.::..:|.
Zfish   178 ----------------SYSDFVRFRP---------------PVREGPVTRSASRAASLHSLSDAS 211

  Fly   644 HDMFRKQPD-VSRILYYKNL-----------GQEE-------LWLDCAEKLTQMIQNIIEFAKLI 689
            .|.|...|: |...|.:.||           ..||       :....|:.::..||.:|.|||:|
Zfish   212 SDSFNHSPESVDTKLNFSNLLMMYQDSGSPDSSEEDQQSRLSMLPHLADLVSYSIQKVIGFAKMI 276

  Fly   690 PGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSD----SEEMRLV 750
            |||..|:.:|||.|||:.:.|:.::|.::...|...:...|.   |...:..:|    ...:.|:
Zfish   277 PGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGG---PDFKYCINDVTKAGHTLELL 338

  Fly   751 SRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLK 815
            ..:.:....:.:|||.|.|..|..::.||.|:|.||:.:..|:.|.:...:.::..:...|   .
Zfish   339 EPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQH---P 400

  Fly   816 GDVTVLDTLLNNIPNFRDISILHME---SLSKFKLQHPNVVFPALYKELF 862
            |...:...::..:.:.|.::..|.:   ||| |:.:|...:.| |..|:|
Zfish   401 GGRLLYAKMIQKLADLRSLNEEHSKQYRSLS-FQPEHSMQLTP-LVLEVF 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	35/111 (32%)
		NR_LBD	620..862	CDD:472173	63/267 (24%)
vdra	NP_570994.1	NR_DBD_VDR	48..154	CDD:143513	36/109 (33%)
		Hinge. /evidence=ECO:0000250|UniProtKB:P11473	129..158		3/28 (11%)
		NR_LBD_VDR	156..452	CDD:132731	73/348 (21%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250|UniProtKB:P13053	274..292		10/17 (59%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473	442..450		4/8 (50%)