DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr3 and Nr1d2

DIOPT Version :10

Sequence 1:NP_001334718.1 Gene:Hr3 / 36073 FlyBaseID:FBgn0000448 Length:871 Species:Drosophila melanogaster
Sequence 2:NP_671743.2 Gene:Nr1d2 / 259241 RGDID:628828 Length:578 Species:Rattus norvegicus


Alignment Length:613 Identity:167/613 - (27%)
Similarity:273/613 - (44%) Gaps:143/613 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   326 PALARS----SSFSSLSSFSSISNISSVC------KNMASNTSQEGSLKRTKERTPPPMPPLTTH 380
            ||...|    :||.|.||....|..||.|      || ...:|.:|.||  .:||.   .|:.|.
  Rat    21 PASCHSEGSENSFQSSSSSVPSSPNSSNCDANGNPKN-TDVSSIDGVLK--SDRTD---CPVKTG 79

  Fly   381 KPAATTTATSATSAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEIIPCKVCGDKSS 445
            ||.|...                          ::.||..:..|.       .::.||||||.:|
  Rat    80 KPGAPGM--------------------------TKSHSGMTKFSG-------MVLLCKVCGDVAS 111

  Fly   446 GVHYGVITCEGCKGFFRRSQSSVVNY-QCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKF 509
            |.||||..|||||||||||....:.| :|.:|:.|.:.|:||||||.||.:|||.:|||||||:|
  Rat   112 GFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRF 176

  Fly   510 GRMSKKQREKVEDEVRFHRAQMRA-------QSDAAPDSSVYDTQTPSSSD------QLHHNNYN 561
            ||:.|::::::..|::.....|.:       |||...:.  ::...|.:.:      ||...|..
  Rat   177 GRIPKREKQRMLIEMQSAMKTMMSTQFGGHLQSDTLAEP--HEQSVPPAQEQLRPKPQLEQENIK 239

  Fly   562 S----GGYSNNEV-G-----------YGSPYGYSASVT---------PQQTMQYDISADYVD--- 598
            |    ..::..|| |           |...:..::|.:         |:...||:::.|:..   
  Rat   240 STPPPSDFAKEEVIGMVTRAHKDTFLYNQEHRENSSESMPPHRGERIPRNVEQYNLNHDHRGGGL 304

  Fly   599 -------------STTYEPRSTIIDP-------------EFISHADGDIND-VLIKTLAEAHA-- 634
                         |..|:.|:.:..|             .|.|.....:.| :.:...::..:  
  Rat   305 HSHFPCSESQQHLSGQYKGRNMMHYPNGHTVCISNGHCVNFSSAYPQRVCDRIPVGGCSQTESRN 369

  Fly   635 ----NTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRL 695
                :|..::..|..| .|.|.|.     ......|:|.:.:...|..::.::||||.||||..|
  Rat   370 SYLCSTGGRMHLVCPM-SKSPYVD-----PQKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDL 428

  Fly   696 SQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEM---RLVSRIFQTA 757
            ||.||:.|||.|:||:.:||.:.|.|..:..|.:    |..:.:...|...|   .|:|.:|:.:
  Rat   429 SQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTF----LSGKKYSVDDLHSMGAGDLLSSMFEFS 489

  Fly   758 KSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLD 822
            :.:..|:|::.|::|:.::||:..:|:|:.....::.|....:.|:|..:..||   ..:.::..
  Rat   490 EKLNGLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH---PNEASIFT 551

  Fly   823 TLLNNIPNFRDISILHMESLSKFKLQHP 850
            .||..:|:.|.::.:|.|.|..||: ||
  Rat   552 KLLLKLPDLRSLNNMHSEELLAFKV-HP 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr3NP_001334718.1 NR_DBD_ROR 430..524 CDD:143526 50/94 (53%)
NR_LBD 620..862 CDD:472173 64/241 (27%)
Nr1d2NP_671743.2 Modulating 1..99 28/116 (24%)
Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q60674 1..60 14/39 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..89 25/99 (25%)
NR_DBD_REV_ERB 98..186 CDD:143540 50/94 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..247 5/34 (15%)
NR_LBD_REV_ERB 388..576 CDD:132738 56/199 (28%)
Interaction with ZNHIT1. /evidence=ECO:0000250 396..578 55/189 (29%)

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