Protein Alignment Hr3 and Ppara

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: XP_006242214.1
• Gene: Ppara / 25747
• RGDID: 3369
• Length: 516
• Species: Rattus norvegicus
• Alignment Length: 614
• Identity: 139/614 - (22%)
• Similarity: 245/614 - (39%)
• Gaps: 146/614 - (23%)

  Fly   290 PEPPAPKRLATTRPAQSRPQQQQQQQQQQVKFLSDPPALARSSSFSSL-----SSFSSISNISSV 349
            |.||.|......|            .|.:..||....:|.......:|     ..|:.:...|.:
  Rat     4 PGPPLPPAFVPFR------------SQLKTSFLGSSLSLWTECQIGALWPAWPQPFNMVDTESPI 56

  Fly   350 C-------KNMASNTSQE-----GSLKRTKERTPPPMPP---------LTTHKPAATTTATSATS 393
            |       .::.|..|:|     |:::...:........         |.:...:..:..|...|
  Rat    57 CPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLS 121

  Fly   394 AAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCK 458
            .|::.|:.:..|..||..|      |..:..|         |.|::||||:||.||||..|||||
  Rat   122 PASSPSSVSCPAVPTSTDE------SPGNALN---------IECRICGDKASGYHYGVHACEGCK 171

  Fly   459 GFFRRSQSSVVNY-QCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVED 522
            |||||:....:.| :|.|:  |.:.:.|||:|||||..|||.:|||.:|::||||.:.::.|::.
  Rat   172 GFFRRTIRLKLAYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKA 234

  Fly   523 EVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHH---NNYN----------SGGYSNNEVGYGS 574
            |:      :..:.| ..||...|.:  |.:.::|.   .|:|          :|..|||
  Rat   235 EI------LTCEHD-LKDSETADLK--SLAKRIHEAYLKNFNMNKVKARVILAGKTSNN------ 284

  Fly   575 PYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTK 639
                                                |.|:.|.        ::||..|......|
  Rat   285 ------------------------------------PPFVIHD--------METLCMAEKTLVAK 305

  Fly   640 LEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLT-QMIQNIIEFAKLIPGFMRLSQDDQILL 703
            :.| :.:..|:.:|.             :..|.:.:: :.:..:.||||.||||..|..:||:.|
  Rat   306 MVA-NGVENKEAEVR-------------FFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTL 356

  Fly   704 LKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTET 768
            ||.|.:|.....:|.|::.....:.||:..:.:|...........::...|..|.....|:|.::
  Rat   357 LKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDS 421

  Fly   769 ELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRD 833
            :::|:.:.::...:|.|:.....|::|....::.::..|::||   ..|..:...||..:.:.|.
  Rat   422 DISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNH---PDDTFLFPKLLQKMVDLRQ 483

  Fly   834 ISILHMESLSKFKLQHPNVVFPALYKELF 862
            :...|.:.:...|....:.....|.:|::
  Rat   484 LVTEHAQLVQVIKKTESDAALHPLLQEIY 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	46/94 (49%)
		NR_LBD	620..862	CDD:472173	49/242 (20%)
Ppara	XP_006242214.1	NR_DBD_Ppar	149..232	CDD:143523	44/84 (52%)
		NR_LBD_PPAR	249..515	CDD:132730	61/333 (18%)