Protein Alignment Hr3 and Ppard

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_037273.2
• Gene: Ppard / 25682
• RGDID: 3370
• Length: 440
• Species: Rattus norvegicus
• Alignment Length: 513
• Identity: 126/513 - (24%)
• Similarity: 216/513 - (42%)
• Gaps: 86/513 - (16%)

  Fly   363 LKRTKERTPPPMPPLTTHKPAATTTATSATSAAAATSAATASATATSARENSREHS---SSSSGS 424
            :::.:|.|    |.....:.....|...|............|::.|...:||...|   ....|.
  Rat     1 MEQPQEET----PEAREEEKEEVATGDGAPELNGGPEHTLPSSSCTDLSQNSSPSSLLDQLQMGC 61

  Fly   425 NGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQ-CPRNKQCVVDRVNRNR 488
            :||....:. :.|:|||||:||.||||..||||||||||:....:.|: |.|  .|.:.:.|||:
  Rat    62 DGASGGSLN-MECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLKYEKCDR--ICKIQKKNRNK 123

  Fly   489 CQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSD 553
            |||||.||||.||||.:|::||||.:.::.|:.               |...:|....|.|..:|
  Rat   124 CQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLV---------------AGLTASEGCQQNPQLAD 173

  Fly   554 QLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHAD 618
            ....:.:....|..|                            .:.|..:.|| |:..:...:|.
  Rat   174 LKAFSKHIYNAYLKN----------------------------FNMTKKKARS-ILTGKSSHNAP 209

  Fly   619 GDINDVLIKTLAEAHANTNTKLEAVHDMFRKQP---DVSRILYYKNLGQEELWLDCAEKLTQMIQ 680
            ..|:|  |:||.:|......|     .:....|   ::|..::|:          |.....:.::
  Rat   210 FIIHD--IETLWQAEKGLVWK-----QLVNGPPPYNEISVHVFYR----------CQSTTVETVR 257

  Fly   681 NIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSE 745
            .:.||||.||.|..|..:||:.|||.|..|.....::.:::.....|..|...:..|...:....
  Rat   258 ELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTHEFLRSIRKP 322

  Fly   746 EMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETN 810
            ...::...|:.|.....|:|.:::|||:.:.::|..:|.|:....:::.:.:..:.|:...|:.|
  Rat   323 FSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPQVEAIQDTILQALEFHLQVN 387

  Fly   811 HAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFK------LQHPNVVFPALYKELF 862
            |...:   .:...||..:.:.|.:...|.:.:...|      |.||  :...:||:::
  Rat   388 HPDSQ---YLFPKLLQKMADLRQLVTEHAQMMQWLKKTESETLLHP--LLQEIYKDMY 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	48/94 (51%)
		NR_LBD	620..862	CDD:472173	53/250 (21%)
Ppard	NP_037273.2	NR_DBD_Ppar	72..155	CDD:143523	47/84 (56%)
		NR_LBD_PPAR	172..439	CDD:132730	61/317 (19%)