Protein Alignment Hr3 and Pparg

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_037256.1
• Gene: Pparg / 25664
• RGDID: 3371
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 146/596 - (24%)
• Similarity: 240/596 - (40%)
• Gaps: 150/596 - (25%)

  Fly   322 LSDPPALARSSSFSS---LSSFSSIS-------------NISSVCKNMASNTSQEGSLK--RTKE 368
            |.|||......:|:.   :|:...|:             .||||..::..:.|....:|  .|.:
  Rat     5 LGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVD 69

  Fly   369 RTPPPMP-----PLTTHKPAAT----TTATSATSAAAATSAATASATATSARENSREHSSSSSGS 424
            .:....|     |.|...|...    ........:|.....|:....:...:..:|.|...   |
  Rat    70 FSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEP---S 131

  Fly   425 NGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRS-QSSVVNYQCPRNKQCVVDRVNRNR 488
            |..|.     |.|:|||||:||.||||..||||||||||: :..::..:|..|  |.:.:.:||:
  Rat   132 NSLMA-----IECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN--CRIHKKSRNK 189

  Fly   489 CQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSD 553
            |||||.||||.:|||.:|::||||.:.::||:..|:                ||..|...|.|:|
  Rat   190 CQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI----------------SSDIDQLNPESAD 238

  Fly   554 --QLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISH 616
              .|..:.|:|             |..|..:|..:.     .|.....||.:....|.|...:..
  Rat   239 LRALAKHLYDS-------------YIKSFPLTKAKA-----RAILTGKTTDKSPFVIYDMNSLMM 285

  Fly   617 ADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQN 681
            .:..|....|..|.|     .:|..|:                      .::..|..:..:.:|.
  Rat   286 GEDKIKFKHITPLQE-----QSKEVAI----------------------RIFQGCQFRSVEAVQE 323

  Fly   682 IIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVL------------------ 728
            |.|:||.||||:.|..:||:.|||.|..|:....::.|  ::::.||
  Rat   324 ITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASL--MNKDGVLISEGQGFMTREFLKSLRK 386

  Fly   729 -YGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEI 792
             :||.|.|:                 |:.|.....|:|.:::||::.::::|..:|.|:.....|
  Rat   387 PFGDFMEPK-----------------FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI 434

  Fly   793 QRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQ------HPN 851
            :.:.:..:.|:..:|:.||..   ...:...:|..:.:.|.|...|::.|...|..      ||
  Rat   435 EDIQDNLLQALELQLKLNHPE---SSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHP- 495

  Fly   852 VVFPALYKELF 862
             :...:||:|:
  Rat   496 -LLQEIYKDLY 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	47/94 (50%)
		NR_LBD	620..862	CDD:472173	55/266 (21%)
Pparg	NP_037256.1	PPARgamma_N	31..108	CDD:463633	12/76 (16%)
		NR_DBD_Ppar	138..221	CDD:143523	45/84 (54%)
		Interaction with FAM120B. /evidence=ECO:0000250	205..280		24/108 (22%)
		NR_LBD_PPAR	237..504	CDD:132730	67/335 (20%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P37231	495..503		2/9 (22%)