Protein Alignment Hr3 and Vdr

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_058754.2
• Gene: Vdr / 24873
• RGDID: 3959
• Length: 423
• Species: Rattus norvegicus
• Alignment Length: 436
• Identity: 106/436 - (24%)
• Similarity: 194/436 - (44%)
• Gaps: 74/436 - (16%)

  Fly   437 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLG 501
            |.||||:::|.|:..:||||||||||||......:.||.|..|.:.:.||..||.|||::|:.:|
  Rat    24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIG 88

  Fly   502 MSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQ----------LH 556
            |.::.:......:::||.:         ..|.:.:|..||     ..|..|::          .|
  Rat    89 MMKEFILTDEEVQRKREMI---------MKRKEEEALKDS-----LRPKLSEEQQHIIAILLDAH 139

  Fly   557 HNNYNSGGYSNNEVGYGSPY---GYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHAD 618
            |..|:. .|::.. .:..|.   |.:.|.:|:.|:.:..::....|..|.....:::|...|:.|
  Rat   140 HKTYDP-TYADFR-DFRPPVRVDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLD 202

  Fly   619 --GDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQN 681
              |:.:|....||                      |:|.:....:|         |:.::..||.
  Rat   203 LNGEDSDDPSVTL----------------------DLSPLSMLPHL---------ADLVSYSIQK 236

  Fly   682 IIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYG------DVMLPQEAFY 740
            :|.|||:||||..|:.||||:|||:.:.|:.::|.::...:...:...|      ||....:|.:
  Rat   237 VIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGH 301

  Fly   741 TSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQ 805
            |     :.|:..:.:....:.:|.|.|.|..|..::.::.|:|.||:....::.:.:...|.::.
  Rat   302 T-----LELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQT 361

  Fly   806 ELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPN 851
            .:...|.| .|...:...::..:.:.|.::..|.:.......|..|
  Rat   362 YIRCRHPP-PGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEN 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	35/86 (41%)
		NR_LBD	620..862	CDD:472173	50/238 (21%)
Vdr	NP_058754.2	NR_DBD_VDR	16..122	CDD:143513	39/111 (35%)
		Hinge. /evidence=ECO:0000250|UniProtKB:P11473	97..126		7/42 (17%)
		NR_LBD_VDR	124..422	CDD:132731	66/322 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..180		4/20 (20%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000269|PubMed:15065852	242..260		11/17 (65%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473	412..420